{"id":"a0ec9968-4ebe-54b5-908f-bc6baad8e330","stable_key":"88eb7407-f147-558b-889b-0c89c4e0aa4a:spermidine-mtorc1","predicate":"reduces_signaling","statement":"Spermidine-associated autophagy induction coincided with inhibition of mTORC1 signaling in the human-cell study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"16a1c31e-634e-557e-a376-b168bb8e9ef0","mechanism_event_label":"A nutrient-sensing signal changed alongside recycling.","subject":{"id":"7014993c-468f-5c6b-ab04-80c87f9dfd9f","slug":"spermidine","display_name":"Spermidine","entity_type_key":"small_molecule"},"object":{"id":"9f025af3-f039-517f-908b-4af6fc65415e","slug":"mtorc1","display_name":"Mechanistic target of rapamycin complex 1","entity_type_key":"protein_complex"},"evidence_count":1,"mechanism_event":{"id":"16a1c31e-634e-557e-a376-b168bb8e9ef0","stable_key":"88eb7407-f147-558b-889b-0c89c4e0aa4a:spermidine-mtorc1-event","event_type":"observed_relationship","label":"A nutrient-sensing signal changed alongside recycling.","description":"Spermidine-associated autophagy induction coincided with inhibition of mTORC1 signaling in the human-cell study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7014993c-468f-5c6b-ab04-80c87f9dfd9f","slug":"spermidine","display_name":"Spermidine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9f025af3-f039-517f-908b-4af6fc65415e","slug":"mtorc1","display_name":"Mechanistic target of rapamycin complex 1","entity_type_key":"protein_complex"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cultured human cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not establish direct binding of spermidine to mTORC1 or a universal rapamycin-like effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Spermidine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"spermidine","display_name":"Spermidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A nutrient-sensing signal changed alongside recycling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Spermidine induces autophagy by inhibiting the acetyltransferase EP300. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25526088/ · DOI 10.1038/cdd.2014.215","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f4c8a951-c0fe-5a39-8f60-b6840986f22f","evidence_kind":"source_excerpt","locator":"Lines 166-172","start_line":166,"end_line":172,"excerpt":"## spermidine-mtorc1\nA nutrient-sensing signal changed alongside recycling.\nSpermidine-associated autophagy induction coincided with inhibition of mTORC1 signaling in the human-cell study.\nModel: Cultured human cells.\nLimitations: Does not establish direct binding of spermidine to mTORC1 or a universal rapamycin-like effect.\nEvidence access: Primary abstract\nSpermidine induces autophagy by inhibiting the acetyltransferase EP300. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25526088/ · DOI 10.1038/cdd.2014.215","model_system":"Cultured human cells.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4348f3f8-0180-58a3-b61c-55d03bb322d2","stable_key":"import-88eb7407-f147-558b-889b-0c89c4e0aa4a","title":"Spermidine: biosynthesis, hypusination, transport and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"8eec8784bc2bd0384cfd53c6603c4ced8e53c227d9ab29ed85594c43e34c68ef","revision_id":"7c421a18-4526-59f6-b84e-4be533bc35ac","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}