{"id":"a0e54254-59b1-523d-a6c1-20ac627b56c2","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iodine-trans-a7-bound-iodide2025","predicate":"binds","statement":"Human SLC26A7 cryo-EM maps in the iodide-loaded state supported iodide assignments at a canonical site and a second site near the gate-domain interface.","claim_class":"identity","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"a9650e91-7c1b-5ca9-b162-2605bba5ff72","mechanism_event_label":"A recent structure directly supports iodide binding by human SLC26A7.","subject":{"id":"6ae2ac42-e051-59b1-aabb-f8263f987ea4","slug":"slc26a7","display_name":"Human SLC26A7 anion transporter","entity_type_key":"protein"},"object":{"id":"83b11ca6-52c7-5a1b-8c39-d9cdf89244e3","slug":"iodide","display_name":"Iodide ion","entity_type_key":"ion"},"evidence_count":1,"mechanism_event":{"id":"a9650e91-7c1b-5ca9-b162-2605bba5ff72","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iodine-trans-a7-bound-iodide2025-event","event_type":"biochemical_relationship","label":"A recent structure directly supports iodide binding by human SLC26A7.","description":"Human SLC26A7 cryo-EM maps in the iodide-loaded state supported iodide assignments at a canonical site and a second site near the gate-domain interface.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"83b11ca6-52c7-5a1b-8c39-d9cdf89244e3","slug":"iodide","display_name":"Iodide ion","entity_type_key":"ion"},"role":"bound_substrate","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6f35aa38-f875-5759-b749-97a2f6480ff3","slug":"chloride-ion","display_name":"Chloride ion","entity_type_key":"ion"},"role":"related_halide_substrate","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6ae2ac42-e051-59b1-aabb-f8263f987ea4","slug":"slc26a7","display_name":"Human SLC26A7 anion transporter","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"true","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Purified human SLC26A7 cryo-EM; recombinant human SLC26A7 in HEK293T cells with whole-cell patch clamp","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Apo and iodide-loaded cryo-EM structures at approximately 3.2 and 3.1 Å; Fig. 2.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Binding-site structures support transport capability but do not establish apical versus basolateral thyroid localization.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iodine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A recent structure directly supports iodide binding by human SLC26A7.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iodine-trans-slc26a7-structure2025] Structural basis for substrate recognition mechanism of human SLC26A7. (2025). https://pubmed.ncbi.nlm.nih.gov/40817112/ DOI: 10.1038/s41467-025-62792-w","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Purified membrane protein","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ce9b3318-2fe0-5cdf-911b-d1ade066df05","evidence_kind":"source_excerpt","locator":"Lines 453-464","start_line":453,"end_line":464,"excerpt":"### iodine-trans-a7-bound-iodide2025\nHuman SLC26A7 cryo-EM maps in the iodide-loaded state supported iodide assignments at a canonical site and a second site near the gate-domain interface.\nCondition category: normal\nnutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A recent structure directly supports iodide binding by human SLC26A7.\norganism: Homo sapiens\ntissue_or_cell_type: Purified membrane protein\nexperimental_model: Purified human SLC26A7 cryo-EM; recombinant human SLC26A7 in HEK293T cells with whole-cell patch clamp\nlimitations: Binding-site structures support transport capability but do not establish apical versus basolateral thyroid localization.\nexposure: Apo and iodide-loaded cryo-EM structures at approximately 3.2 and 3.1 Å; Fig. 2.\ncross_nutrient: true\n[iodine-trans-slc26a7-structure2025] Structural basis for substrate recognition mechanism of human SLC26A7. (2025). https://pubmed.ncbi.nlm.nih.gov/40817112/ DOI: 10.1038/s41467-025-62792-w","model_system":"Purified human SLC26A7 cryo-EM; recombinant human SLC26A7 in HEK293T cells with whole-cell patch clamp","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [iodine-trans-slc26a7-structure2025] Structural basis for substrate recognition mechanism of human SLC26A7. (2025). https://pubmed.ncbi.nlm.nih.gov/40817112/ DOI: 10.1038/s41467-025-62792-w","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"76da623d-a34a-5a5c-a942-d7571a85c486","stable_key":"import-aaa7baba-8689-56ab-ba1e-b71542bcb8e9","title":"Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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