{"id":"a0956d1b-f8fa-5b27-aa0a-bed77c3b4233","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-thromboembolism-signal","predicate":"associated_with","statement":"VTE odds ratios were 1.24 (95% CI 0.96–1.61) for current ranelate versus current bisphosphonate use and 1.30 (1.04–1.62) for current versus past ranelate use.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b380676e-74b4-5839-a44a-a600b9e2f3a2","mechanism_event_label":"The VTE signal depended partly on the comparator, and one interval included no increase.","subject":{"id":"a319eca8-b0ed-5a8c-8659-e7f106bed73a","slug":"strontium-ranelate","display_name":"Strontium ranelate","entity_type_key":"chemical_species"},"object":{"id":"a6c7b5f9-b9ff-5c95-aeff-636ffa0011c6","slug":"human-ranelate-vte","display_name":"Venous thromboembolism in ranelate observational cohorts","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b380676e-74b4-5839-a44a-a600b9e2f3a2","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-thromboembolism-signal-event","event_type":"observed_relationship","label":"The VTE signal depended partly on the comparator, and one interval included no increase.","description":"VTE odds ratios were 1.24 (95% CI 0.96–1.61) for current ranelate versus current bisphosphonate use and 1.30 (1.04–1.62) for current versus past ranelate use.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a319eca8-b0ed-5a8c-8659-e7f106bed73a","slug":"strontium-ranelate","display_name":"Strontium ranelate","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a6c7b5f9-b9ff-5c95-aeff-636ffa0011c6","slug":"human-ranelate-vte","display_name":"Venous thromboembolism in ranelate observational cohorts","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2ca2864b-1ef0-54e4-8397-1dbe7207a0d2","slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same multinational observational database study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Association does not establish a coagulation mechanism; do not transfer numerical risks to all salts or doses.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"The VTE signal depended partly on the comparator, and one interval included no increase.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Comparative cardiovascular safety of strontium ranelate and bisphosphonates: a multi-database study in 5 EU countries by the EU-ADR Alliance. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32757044/ · DOI 10.1007/s00198-020-05580-0","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0f319f13-f5ff-5124-8215-758e2442a207","evidence_kind":"source_excerpt","locator":"Lines 446-452","start_line":446,"end_line":452,"excerpt":"## strontium-thromboembolism-signal\nThe VTE signal depended partly on the comparator, and one interval included no increase.\nVTE odds ratios were 1.24 (95% CI 0.96–1.61) for current ranelate versus current bisphosphonate use and 1.30 (1.04–1.62) for current versus past ranelate use.\nModel: Same multinational observational database study.\nLimitations: Association does not establish a coagulation mechanism; do not transfer numerical risks to all salts or doses.\nEvidence access: Primary abstract\nComparative cardiovascular safety of strontium ranelate and bisphosphonates: a multi-database study in 5 EU countries by the EU-ADR Alliance. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32757044/ · DOI 10.1007/s00198-020-05580-0","model_system":"Same multinational observational database study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"43ef0fe7-eb6c-5346-8381-f7694733b4dc","stable_key":"import-1ff3a29f-ef80-5bff-9300-30b98c60b90d","title":"Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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