{"id":"a07907ae-3eef-565a-a016-c19ceb0e65bd","stable_key":"97957230-601f-5dec-8524-0812be8fadbf:l-threonine-nkh-amino-acid-pattern","predicate":"is_elevated_in","statement":"Compared with age-adjusted controls, NKH patients had higher CSF threonine, lower serine and higher glycine.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"60e1ee87-9271-57cf-a3ea-b7554dc12a92","mechanism_event_label":"A high amino-acid measurement can accompany a defect in a neighboring pathway.","subject":{"id":"fcef4dc2-a7b6-5812-bc33-c8af3d83f4d0","slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"},"object":{"id":"d58d86a6-b00b-5831-a96a-af25f74ee43a","slug":"human-nkh-csf-threonine","display_name":"CSF threonine in genetically confirmed nonketotic hyperglycinemia","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"60e1ee87-9271-57cf-a3ea-b7554dc12a92","stable_key":"97957230-601f-5dec-8524-0812be8fadbf:l-threonine-nkh-amino-acid-pattern-event","event_type":"observed_relationship","label":"A high amino-acid measurement can accompany a defect in a neighboring pathway.","description":"Compared with age-adjusted controls, NKH patients had higher CSF threonine, lower serine and higher glycine.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fcef4dc2-a7b6-5812-bc33-c8af3d83f4d0","slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d58d86a6-b00b-5831-a96a-af25f74ee43a","slug":"human-nkh-csf-threonine","display_name":"CSF threonine in genetically confirmed nonketotic hyperglycinemia","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2b507258-430c-51fe-9fd2-e510c2c197a9","slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"c882cd0b-9d83-5b07-bd1c-fe4d45657dcb","slug":"l-serine","display_name":"L-Serine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"7f3bf9f5-b1b1-5381-baa6-72800ceb5436","slug":"d-serine","display_name":"D-Serine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"61 genetically confirmed patients versus reference data from 274 controls; stereoselective serine analysis in a smaller subset.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Association does not identify a unique transport mechanism or justify treating an isolated CSF ratio.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Threonine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A high amino-acid measurement can accompany a defect in a neighboring pathway.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Cerebrospinal fluid amino acids glycine, serine, and threonine in nonketotic hyperglycinemia. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35357708/ · DOI 10.1002/jimd.12500","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"6cff3172-5ae5-55ce-9b26-72b04d67d37f","evidence_kind":"source_excerpt","locator":"Lines 418-424","start_line":418,"end_line":424,"excerpt":"## l-threonine-nkh-amino-acid-pattern\nA high amino-acid measurement can accompany a defect in a neighboring pathway.\nCompared with age-adjusted controls, NKH patients had higher CSF threonine, lower serine and higher glycine.\nModel: 61 genetically confirmed patients versus reference data from 274 controls; stereoselective serine analysis in a smaller subset.\nLimitations: Association does not identify a unique transport mechanism or justify treating an isolated CSF ratio.\nEvidence access: Primary abstract\nCerebrospinal fluid amino acids glycine, serine, and threonine in nonketotic hyperglycinemia. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35357708/ · DOI 10.1002/jimd.12500","model_system":"61 genetically confirmed patients versus reference data from 274 controls; stereoselective serine analysis in a smaller subset.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"35396730-235a-537e-8a05-c6ef2960c509","stable_key":"import-97957230-601f-5dec-8524-0812be8fadbf","title":"L-Threonine: translation, intestinal barrier, metabolism and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"3365aed939d9f567bd098449c7d67c7c00fb6c9ba163dcf34dc7cf6081f324fb","revision_id":"10a7b648-8dd7-5d4e-b618-c560a6e2d3c7","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}