{"id":"a0501697-e40a-59d4-ae29-fdf48eea9735","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:intestinal-trpm7-loss-zinc","predicate":"reduces","statement":"Intestinal Trpm7 deletion reduced circulating zinc in early postnatal mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"c1e0bb08-3154-5898-af13-f52c73629608","mechanism_event_label":"A single epithelial machinery defect depleted zinc along with magnesium.","subject":{"id":"8aa56c51-adf5-53a8-926c-f66c00a0f4a5","slug":"mouse-intestinal-trpm7-null-genotype","display_name":"Intestine-specific Trpm7-null mouse genotype","entity_type_key":"gene"},"object":{"id":"d78e85a6-2637-50ff-8935-c946a7fc8761","slug":"serum-zinc-concentration","display_name":"Serum zinc concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c1e0bb08-3154-5898-af13-f52c73629608","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:intestinal-trpm7-loss-zinc-event","event_type":"biochemical_relationship","label":"A single epithelial machinery defect depleted zinc along with magnesium.","description":"Intestinal Trpm7 deletion reduced circulating zinc in early postnatal mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"16ade5d1-e269-5904-9ab1-b285509b7aef","slug":"trpm7","display_name":"TRPM7","entity_type_key":"protein"},"role":"shared-channel","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"49c806c2-7041-5020-8b3b-fa04ffa122ac","slug":"zinc-ion","display_name":"Zinc(II) ion","entity_type_key":"ion"},"role":"affected-nutrient-ion","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"role":"coaffected-nutrient-ion","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"8aa56c51-adf5-53a8-926c-f66c00a0f4a5","slug":"mouse-intestinal-trpm7-null-genotype","display_name":"Intestine-specific Trpm7-null mouse genotype","entity_type_key":"gene"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"d78e85a6-2637-50ff-8935-c946a7fc8761","slug":"serum-zinc-concentration","display_name":"Serum zinc concentration","entity_type_key":"cellular_process"},"role":"object","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Shared intestinal TRPM7 machinery links zinc and magnesium availability; Mg deficiency as the cause of Zn deficiency was not demonstrated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence-system","value_text":"Conditional intestinal knockout and mineral phenotyping","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Conditional intestinal knockout and mineral phenotyping","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not evidence that magnesium supplementation universally increases zinc absorption.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Magnesium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mouse","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A single epithelial machinery defect depleted zinc along with magnesium.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mittermeier-2019-trpm7] TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival (2019). https://pubmed.ncbi.nlm.nih.gov/30770447/ DOI: 10.1073/pnas.1810633116","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Intestine; serum","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestine; serum","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"5497cb5e-a104-504f-b179-8687344bbc3f","evidence_kind":"source_excerpt","locator":"Lines 1002-1014","start_line":1002,"end_line":1014,"excerpt":"### intestinal-trpm7-loss-zinc\nIntestinal Trpm7 deletion reduced circulating zinc in early postnatal mice.\nCondition category: machinery_impairment\nnutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A single epithelial machinery defect depleted zinc along with magnesium.\norganism: Mouse\ntissue_or_cell_type: Intestine; serum\nexperimental_model: Conditional intestinal knockout and mineral phenotyping\nlimitations: Not evidence that magnesium supplementation universally increases zinc absorption.\ncross_nutrient: Shared intestinal TRPM7 machinery links zinc and magnesium availability; Mg deficiency as the cause of Zn deficiency was not demonstrated.\nevidence-system: Conditional intestinal knockout and mineral phenotyping\ntissue: Intestine; serum\n[mittermeier-2019-trpm7] TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival (2019). https://pubmed.ncbi.nlm.nih.gov/30770447/ DOI: 10.1073/pnas.1810633116","model_system":"Conditional intestinal knockout and mineral phenotyping","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [mittermeier-2019-trpm7] TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival (2019). https://pubmed.ncbi.nlm.nih.gov/30770447/ DOI: 10.1073/pnas.1810633116","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e111c412f57143a17e8e65e74e8f7888b5bb9a61099873f4767f527fac19bb07","revision_id":"6b7f04f2-66ed-5859-955f-c2b50d4bf041","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}