{"id":"a044da6d-9e72-5c77-a2e7-e34326290d5d","stable_key":"792249b7-a38d-5f43-afb6-2936818a3fa2:tartrazine-sulfanilic-product","predicate":"is_reduced_to","statement":"Tartrazine azo reduction yields sulfanilic acid as one of the cleavage products.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"7c529b2d-81c0-5c91-ae91-49602f15ec33","mechanism_event_label":"Tartrazine azo reduction yields sulfanilic acid as one of the cleavage products.","subject":{"id":"135b5f4d-0c59-5359-a645-39796e820d42","slug":"tartrazine","display_name":"Tartrazine","entity_type_key":"small_molecule"},"object":{"id":"f0f532e0-d3c7-5f4f-a9de-a979cd031bae","slug":"sulfanilic-acid","display_name":"Sulfanilic acid","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"7c529b2d-81c0-5c91-ae91-49602f15ec33","stable_key":"792249b7-a38d-5f43-afb6-2936818a3fa2:tartrazine-sulfanilic-product-event","event_type":"observed_relationship","label":"Tartrazine azo reduction yields sulfanilic acid as one of the cleavage products.","description":"Tartrazine azo reduction yields sulfanilic acid as one of the cleavage products.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"135b5f4d-0c59-5359-a645-39796e820d42","slug":"tartrazine","display_name":"Tartrazine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f0f532e0-d3c7-5f4f-a9de-a979cd031bae","slug":"sulfanilic-acid","display_name":"Sulfanilic acid","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Tartrazine/isolated metabolites; preparative concentrations not recovered from primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Reaction intervals not recovered from accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract; unrecovered method details explicitly retained.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; source-specific experimental curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human-stool bacterial isolates and analytical chemistry of tartrazine products","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"SCAP and PPA identities were experimentally characterized. The additional yellow derivative remains proposed and is not imported as an established metabolite. Human circulating exposure was not measured.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Tartrazine food-colorant chapter; nutrient, drug and peptide interactions retain their models and limits.","comparator":null,"unit":null,"notes":"","entity":{"slug":"tartrazine","display_name":"Tartrazine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human-stool bacterial isolates and analytical chemistry of tartrazine products","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Tartrazine azo reduction yields sulfanilic acid as one of the cleavage products.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Preparation, analysis and toxicity characterisation of the redox metabolites of the azo food dye tartrazine. (2023). https://pubmed.ncbi.nlm.nih.gov/37980979/ DOI: 10.1016/j.fct.2023.114193","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro biotransformation and chemical characterization","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Azo reduction followed by oxidation on exposure to air","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3d9efe2e-0704-5105-8398-ac733bf1c7fa","evidence_kind":"source_excerpt","locator":"Lines 83-92","start_line":83,"end_line":92,"excerpt":"## tartrazine-sulfanilic-product\nTartrazine azo reduction yields sulfanilic acid as one of the cleavage products.\nModel/species: Human-stool bacterial isolates and analytical chemistry of tartrazine products\nTissue: Azo reduction followed by oxidation on exposure to air\nExposure: Tartrazine/isolated metabolites; preparative concentrations not recovered from primary abstract\nRoute: In vitro biotransformation and chemical characterization\nDuration: Reaction intervals not recovered from accessed abstract\nLimits: SCAP and PPA identities were experimentally characterized. The additional yellow derivative remains proposed and is not imported as an established metabolite. Human circulating exposure was not measured.\nPrimary reference: Preparation, analysis and toxicity characterisation of the redox metabolites of the azo food dye tartrazine. (2023). https://pubmed.ncbi.nlm.nih.gov/37980979/ DOI: 10.1016/j.fct.2023.114193\nAccess: Primary PubMed abstract; unrecovered method details explicitly retained.","model_system":"Human-stool bacterial isolates and analytical chemistry of tartrazine products","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span, not a publisher quotation; primary citation retained.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"d9540941-68b4-5a0d-a5c1-828665a918e2","stable_key":"import-792249b7-a38d-5f43-afb6-2936818a3fa2","title":"Tartrazine: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of eighteen primary studies. Study-specific citations, negative findings and limitations retained. 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