{"id":"9fb36ba4-282a-5cf2-b5f0-3abb027e9b5c","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-ckd-kcl-plasma-rise","predicate":"supplementation_increases","statement":"Two weeks of KCl raised mean plasma potassium from 4.3 to 4.7 mmol/L; 21 of 191 CKD participants developed hyperkalemia.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"073d147b-d35f-5e39-b0bb-51234eb373c9","mechanism_event_label":"Reduced kidney clearance changes the response to an added potassium load.","subject":{"id":"9a56258e-7dda-5b6a-9a14-58c9fe1856c3","slug":"potassium-chloride","display_name":"Potassium chloride","entity_type_key":"chemical_species"},"object":{"id":"bb23d568-e85f-5bdd-b264-92d73b8dce53","slug":"plasma-potassium-concentration","display_name":"Plasma potassium concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"073d147b-d35f-5e39-b0bb-51234eb373c9","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-ckd-kcl-plasma-rise-event","event_type":"observed_intervention","label":"Reduced kidney clearance changes the response to an added potassium load.","description":"Two weeks of KCl raised mean plasma potassium from 4.3 to 4.7 mmol/L; 21 of 191 CKD participants developed hyperkalemia.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"role":"loaded_ion","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9a56258e-7dda-5b6a-9a14-58c9fe1856c3","slug":"potassium-chloride","display_name":"Potassium chloride","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"bb23d568-e85f-5bdd-b264-92d73b8dce53","slug":"plasma-potassium-concentration","display_name":"Plasma potassium concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Uncontrolled run-in; CKD G3b-4.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"40 mmol/day KCl; 83% used RAAS inhibitors.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"11% is this cohort rate, not general-population risk or a dose recommendation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Reduced kidney clearance changes the response to an added potassium load.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[k-gritter2022] Effects of Short-Term Potassium Chloride Supplementation in Patients with CKD (2022). https://pubmed.ncbi.nlm.nih.gov/35609996/ DOI: 10.1681/asn.2022020147","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9537bf1d-f1e7-54f0-a81b-947fc89c2a08","evidence_kind":"source_excerpt","locator":"Lines 1638-1648","start_line":1638,"end_line":1648,"excerpt":"### k-ckd-kcl-plasma-rise\nTwo weeks of KCl raised mean plasma potassium from 4.3 to 4.7 mmol/L; 21 of 191 CKD participants developed hyperkalemia.\nCondition category: normal\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Reduced kidney clearance changes the response to an added potassium load.\norganism: Homo sapiens\ntissue_or_cell_type: Plasma\nexperimental_model: Uncontrolled run-in; CKD G3b-4.\nlimitations: 11% is this cohort rate, not general-population risk or a dose recommendation.\nexposure: 40 mmol/day KCl; 83% used RAAS inhibitors.\n[k-gritter2022] Effects of Short-Term Potassium Chloride Supplementation in Patients with CKD (2022). https://pubmed.ncbi.nlm.nih.gov/35609996/ DOI: 10.1681/asn.2022020147","model_system":"Uncontrolled run-in; CKD G3b-4.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [k-gritter2022] Effects of Short-Term Potassium Chloride Supplementation in Patients with CKD (2022). https://pubmed.ncbi.nlm.nih.gov/35609996/ DOI: 10.1681/asn.2022020147","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"241226ee-6b7d-5cc7-9781-e6beb8ee1982","stable_key":"import-5102beb6-9f61-500e-af10-9ac63649e0b7","title":"Potassium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a8f89f8d84b48c0f93048dfc45f7f57a67dd9a7249968a096a14aeb03d8b7a52","revision_id":"de4ec6f4-58a1-537b-8169-97b783898df1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}