{"id":"9f8bf66b-4482-5184-ad89-dfaca0af8f68","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-sanders-falls","predicate":"increases-under-annual-bolus-regimen","statement":"Fall incidence was higher with annual D3 (rate ratio 1.15; 95% CI1.02–1.30; P=0.03).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"cb2d6b49-2578-5600-aead-aa6092973e3c","mechanism_event_label":"The annual megadose increased falls rather than preventing them.","subject":{"id":"b162e431-b442-5400-9335-ec91f7875a4e","slug":"cholecalciferol","display_name":"Cholecalciferol","entity_type_key":"small_molecule"},"object":{"id":"41a6acdf-d767-5f4f-b56f-64e060d1b35e","slug":"fall-incidence","display_name":"Incidence of falls","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"cb2d6b49-2578-5600-aead-aa6092973e3c","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-sanders-falls-event","event_type":"observed_intervention","label":"The annual megadose increased falls rather than preventing them.","description":"Fall incidence was higher with annual D3 (rate ratio 1.15; 95% CI1.02–1.30; P=0.03).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b162e431-b442-5400-9335-ec91f7875a4e","slug":"cholecalciferol","display_name":"Cholecalciferol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"41a6acdf-d767-5f4f-b56f-64e060d1b35e","slug":"fall-incidence","display_name":"Incidence of falls","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"2256 community-dwelling women aged≥ 70; annual-bolus randomized placebo-controlled trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"500, 000 IU oral D3 each autumn/winter for 3–5 years.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Annual very large bolus in older women; does not demonstrate that all D3 regimens raise risk.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-d","display_name":"Vitamin D2 and D3","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The annual megadose increased falls rather than preventing them.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[sanders2010] Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. (2010). https://pubmed.ncbi.nlm.nih.gov/20460620/ DOI: 10.1001/jama.2010.594","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Clinical falls","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"fda6b96a-84a5-5c72-ace9-80c8126b5df4","evidence_kind":"source_excerpt","locator":"Lines 1574-1585","start_line":1574,"end_line":1585,"excerpt":"### vd-sanders-falls\nFall incidence was higher with annual D3 (rate ratio 1.15; 95% CI1.02–1.30; P=0.03).\nCondition category: normal\nnutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The annual megadose increased falls rather than preventing them.\norganism: Homo sapiens\ntissue_or_cell_type: Clinical falls\nexperimental_model: 2256 community-dwelling women aged≥ 70; annual-bolus randomized placebo-controlled trial\nlimitations: Annual very large bolus in older women; does not demonstrate that all D3 regimens raise risk.\nexposure: 500, 000 IU oral D3 each autumn/winter for 3–5 years.\ncross_nutrient: false\n[sanders2010] Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. (2010). https://pubmed.ncbi.nlm.nih.gov/20460620/ DOI: 10.1001/jama.2010.594","model_system":"2256 community-dwelling women aged≥ 70; annual-bolus randomized placebo-controlled trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [sanders2010] Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. (2010). https://pubmed.ncbi.nlm.nih.gov/20460620/ DOI: 10.1001/jama.2010.594","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c95c763c-5b31-5b3f-a2f8-2dfe5ef0d3ca","stable_key":"import-1deb434a-3547-51a0-a038-87b1ce79ec38","title":"Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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