{"id":"9f6f2ba2-78a5-599c-b71e-818433909cea","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:food-intake","predicate":"decreases_in_recorded_experiment","statement":"In eleven simulated-shift-work volunteers, 200 and 400 mg modafinil reduced caloric intake about 18% and 38%, respectively, across three exposure days.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"5acbe7e5-00e0-5fcd-99fa-6140c6ce0b41","mechanism_event_label":"In eleven simulated-shift-work volunteers, 200 and 400 mg modafinil reduced caloric intake about 18% and 38%, respectively, across three exposure days.","subject":{"id":"624e6a4b-f96d-5d12-8206-30d1e1715c26","slug":"modafinil","display_name":"Modafinil","entity_type_key":"drug"},"object":{"id":"fab423fc-587a-54d6-8117-8efef9fb0f78","slug":"caloric-intake","display_name":"Caloric intake","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5acbe7e5-00e0-5fcd-99fa-6140c6ce0b41","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:food-intake-event","event_type":"experimental_observation","label":"In eleven simulated-shift-work volunteers, 200 and 400 mg modafinil reduced caloric intake about 18% and 38%, respectively, across three exposure days.","description":"In a double-blind simulated-shift-work study of **11 volunteers**, secondary analysis found approximately **18% and 38% lower caloric intake** with 200 and 400 mg modafinil, respectively. The proportions of calories from carbohydrate, fat and protein did not selectively change. Hunger ratings changed only at particular assessments; reduced intake remained across three exposure days. This supports an intake effect under those conditions, not demonstrated vitamin/mineral deficiency or a long-term weight-loss outcome. [Human food-intake study](https://pubmed.ncbi.nlm.nih.gov/18573275/)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"624e6a4b-f96d-5d12-8206-30d1e1715c26","slug":"modafinil","display_name":"Modafinil","entity_type_key":"drug"},"role":"tested factor","stoichiometry":null,"state_label":"200 or 400 mg modafinil","sequence_order":0,"notes":""},{"entity":{"id":"fab423fc-587a-54d6-8117-8efef9fb0f78","slug":"caloric-intake","display_name":"Caloric intake","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"decrease","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary indexed abstract checked; full methods and figures not comprehensively reviewed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"200 or 400 mg modafinil\", \"comparator\": \"Placebo\", \"endpoint\": \"In eleven simulated-shift-work volunteers, 200 and 400 mg modafinil reduced caloric intake about 18% and 38%, respectively, across three exposure days.\", \"effect_direction\": \"decrease\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"Human double-blind simulated shift work; secondary intake analysis; short exposure, not long-term nutritional-deficiency measurement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. 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The proportions of calories from carbohydrate, fat and protein did not selectively change. Hunger ratings changed only at particular assessments; reduced intake remained across three exposure days. This supports an intake effect under those conditions, not demonstrated vitamin/mineral deficiency or a long-term weight-loss outcome. [Human food-intake study](https://pubmed.ncbi.nlm.nih.gov/18573275/)","model_system":"Human double-blind simulated shift work; secondary intake analysis; short exposure, not long-term nutritional-deficiency measurement.","directness":"reported_statement","verification_status":"source_recorded","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. 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