{"id":"9f4b131f-358c-5943-beed-19e258c731e8","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-tocotrienol-hypothesis","predicate":"predicted_interaction_with","statement":"Calculated structures predicted hydrogen bonding between alpha-tocotrienol and astaxanthin as a possible explanation of the measured combination effect.","claim_class":"hypothesis_link","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ca194676-7883-5945-b292-c850253600d2","mechanism_event_label":"A molecular interaction was proposed to explain the synergy.","subject":{"id":"45597684-ead7-5ebe-975a-ac3bc714e22c","slug":"alpha-tocotrienol","display_name":"Alpha-tocotrienol","entity_type_key":"small_molecule"},"object":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"ca194676-7883-5945-b292-c850253600d2","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-tocotrienol-hypothesis-event","event_type":"observed_relationship","label":"A molecular interaction was proposed to explain the synergy.","description":"Calculated structures predicted hydrogen bonding between alpha-tocotrienol and astaxanthin as a possible explanation of the measured combination effect.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"45597684-ead7-5ebe-975a-ac3bc714e22c","slug":"alpha-tocotrienol","display_name":"Alpha-tocotrienol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Computational structure analysis accompanying the liposome experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The proposed contact was not directly demonstrated in human membranes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A molecular interaction was proposed to explain the synergy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Synergistic antioxidative effect of astaxanthin and tocotrienol by co-encapsulated in liposomes. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27698536/ · DOI 10.3164/jcbn.15-153","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"951bfdc8-4894-5e6b-9214-2248bb02f873","evidence_kind":"source_excerpt","locator":"Lines 206-212","start_line":206,"end_line":212,"excerpt":"## astaxanthin-tocotrienol-hypothesis\nA molecular interaction was proposed to explain the synergy.\nCalculated structures predicted hydrogen bonding between alpha-tocotrienol and astaxanthin as a possible explanation of the measured combination effect.\nModel: Computational structure analysis accompanying the liposome experiment.\nLimitations: The proposed contact was not directly demonstrated in human membranes.\nEvidence access: Primary abstract\nSynergistic antioxidative effect of astaxanthin and tocotrienol by co-encapsulated in liposomes. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27698536/ · DOI 10.3164/jcbn.15-153","model_system":"Computational structure analysis accompanying the liposome experiment.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"98640e32f62e6c0387578165342ad21b3d2325701fcfdbb5c48886c783040e5e","revision_id":"a82757ce-1feb-582c-a5fc-f7de36308f1f","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}