{"id":"9f48c021-ec93-54cb-a12c-176fb69a854e","stable_key":"8b3cf083-ea9c-54f5-b42b-bf1fef5b2978:metformin-human-glycogenolysis","predicate":"reduces","statement":"The authors concluded that suppression of accelerated basal hepatic glucose production was most likely secondary to an inhibition of hepatic glycogenolysis, since the percentage of gluconeogenesis from lactate and the rate of lactate-derived gluconeogenesis were unchanged.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"4d8985a8-a8a0-54de-b8fe-2aae2576e89c","mechanism_event_label":"The reduction came from breaking down stored glycogen less, not from making less new glucose.","subject":{"id":"519971b1-5aef-5ad7-8022-840144855cd0","slug":"metformin","display_name":"Metformin","entity_type_key":"drug"},"object":{"id":"41818601-61fa-575f-8345-1d3bbe15d90a","slug":"hepatic-glycogenolysis","display_name":"Hepatic glycogenolysis","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4d8985a8-a8a0-54de-b8fe-2aae2576e89c","stable_key":"8b3cf083-ea9c-54f5-b42b-bf1fef5b2978:metformin-human-glycogenolysis-event","event_type":"observed_intervention","label":"The reduction came from breaking down stored glycogen less, not from making less new glucose.","description":"The authors concluded that suppression of accelerated basal hepatic glucose production was most likely secondary to an inhibition of hepatic glycogenolysis, since the percentage of gluconeogenesis from lactate and the rate of lactate-derived gluconeogenesis were unchanged.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c47e645c-a6d3-5784-81b9-81a93ca2bd68","slug":"gluconeogenesis-from-lactate","display_name":"Gluconeogenesis from lactate and glycerol","entity_type_key":"cellular_process"},"role":"unchanged_process","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"519971b1-5aef-5ad7-8022-840144855cd0","slug":"metformin","display_name":"Metformin","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"41818601-61fa-575f-8345-1d3bbe15d90a","slug":"hepatic-glycogenolysis","display_name":"Hepatic glycogenolysis","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/metformin-research/8923861.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"164b296465a3d5730d3dba4c66062ce97c227e61b866b6a42c5beb772f51d688\", \"start_char\": 0, \"end_char\": 3516, \"text_sha256\": \"164b296465a3d5730d3dba4c66062ce97c227e61b866b6a42c5beb772f51d688\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomised double-blind placebo-controlled trial with tracer infusions and euglycaemic clamp","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"15 weeks of metformin versus placebo in 20 people with type 2 diabetes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Tracer measurement of where the glucose effect comes from. Lactate turnover was measured directly and did not change, which bears on lactate safety questions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Metformin research collection; topical membership is not evidence of a direct clinical effect, and pharmacological exposure is not dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"metformin","display_name":"Metformin","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The reduction came from breaking down stored glycogen less, not from making less new glucose.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[metformin-p8923861] Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus. 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Lactate turnover was measured directly and did not change, which bears on lactate safety questions.\nexposure: 15 weeks of metformin versus placebo in 20 people with type 2 diabetes\nevidence_span: {\"source_cache\": \"artifacts/metformin-research/8923861.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"164b296465a3d5730d3dba4c66062ce97c227e61b866b6a42c5beb772f51d688\", \"start_char\": 0, \"end_char\": 3516, \"text_sha256\": \"164b296465a3d5730d3dba4c66062ce97c227e61b866b6a42c5beb772f51d688\"}\n[metformin-p8923861] Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus. 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