{"id":"9f2815f4-5acc-514d-8718-62d38ea405e8","stable_key":"3279ff78-2460-5064-bfc0-3f2987af85a0:melatonin-beta-blocker-sleep-efficiency","predicate":"increases","statement":"Sleep efficiency increased by about 7.6 percentage points compared with placebo in beta-blocker-treated patients.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"0857d99f-d81b-541b-9cc0-7f01c6523082","mechanism_event_label":"This is a measured sleep outcome in a specific medication context.","subject":{"id":"0f0bc1f1-d18d-5652-bc1d-98f61f7ab65c","slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"},"object":{"id":"d6952176-91b8-5bb1-8bf6-ed91ba3c8155","slug":"psg-sleep-efficiency","display_name":"Polysomnographic sleep efficiency","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0857d99f-d81b-541b-9cc0-7f01c6523082","stable_key":"3279ff78-2460-5064-bfc0-3f2987af85a0:melatonin-beta-blocker-sleep-efficiency-event","event_type":"observed_intervention","label":"This is a measured sleep outcome in a specific medication context.","description":"Sleep efficiency increased by about 7.6 percentage points compared with placebo in beta-blocker-treated patients.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5af8304e-4059-5331-88c9-4ecf49ab805f","slug":"atenolol","display_name":"Atenolol","entity_type_key":"small_molecule"},"role":"background_medication_option","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b9e44f90-71b9-5cc0-920b-d50ab8a70fe1","slug":"metoprolol","display_name":"Metoprolol","entity_type_key":"small_molecule"},"role":"background_medication_option","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0f0bc1f1-d18d-5652-bc1d-98f61f7ab65c","slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"d6952176-91b8-5bb1-8bf6-ed91ba3c8155","slug":"psg-sleep-efficiency","display_name":"Polysomnographic sleep efficiency","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/melatonin-research/23024438.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0f886545db45f7067ce68991935dcc3715082dbe31898c939eb64b015d3581f3\", \"start_char\": 0, \"end_char\": 2402, \"text_sha256\": \"0f886545db45f7067ce68991935dcc3715082dbe31898c939eb64b015d3581f3\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind placebo-controlled trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"2.5 mg melatonin nightly for three weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small selected group; does not prove every beta-blocker user is deficient or that all low-melatonin states respond identically.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Melatonin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Hypertensive patients taking atenolol or metoprolol; 15 analyzed","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"This is a measured sleep outcome in a specific medication context.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[melatonin-p23024438] Repeated melatonin supplementation improves sleep in hypertensive patients treated with beta-blockers: a randomized controlled trial. (2012). https://pubmed.ncbi.nlm.nih.gov/23024438/ DOI: 10.5665/sleep.2122","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Polysomnographic sleep","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"940364cf-304b-5cec-8667-a18620f4ae6b","evidence_kind":"source_excerpt","locator":"Lines 994-1005","start_line":994,"end_line":1005,"excerpt":"### melatonin-beta-blocker-sleep-efficiency\nSleep efficiency increased by about 7.6 percentage points compared with placebo in beta-blocker-treated patients.\nCondition category: normal\nnutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: This is a measured sleep outcome in a specific medication context.\norganism: Hypertensive patients taking atenolol or metoprolol; 15 analyzed\ntissue_or_cell_type: Polysomnographic sleep\nexperimental_model: Randomized double-blind placebo-controlled trial\nlimitations: Small selected group; does not prove every beta-blocker user is deficient or that all low-melatonin states respond identically.\nexposure: 2.5 mg melatonin nightly for three weeks\nevidence_span: {\"source_cache\": \"artifacts/melatonin-research/23024438.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0f886545db45f7067ce68991935dcc3715082dbe31898c939eb64b015d3581f3\", \"start_char\": 0, \"end_char\": 2402, \"text_sha256\": \"0f886545db45f7067ce68991935dcc3715082dbe31898c939eb64b015d3581f3\"}\n[melatonin-p23024438] Repeated melatonin supplementation improves sleep in hypertensive patients treated with beta-blockers: a randomized controlled trial. 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