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(2005). https://pubmed.ncbi.nlm.nih.gov/15878708/ DOI: 10.1016/j.ejphar.2005.03.007","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Liver mitochondria","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8777839d-ce83-5df8-a2ca-9d79c52f3da8","evidence_kind":"source_excerpt","locator":"Lines 666-677","start_line":666,"end_line":677,"excerpt":"### mangiferin-iron-lipid\nMangiferin inhibited ferrous-citrate-triggered mitochondrial lipid peroxidation.\nCondition category: normal\nnutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Binding iron altered its ability to drive membrane oxidation.\norganism: Rattus norvegicus and cell-free chemistry\ntissue_or_cell_type: Liver mitochondria\nexperimental_model: Isolated mitochondrial and iron-redox assays\nlimitations: In vitro iron complexing is not evidence that oral mangiferin depletes body iron or treats iron overload.\nexposure: 10 micromolar mangiferin and 50 micromolar ferrous citrate in one protection experiment\nevidence_span: {\"source_cache\": \"artifacts/mangiferin-research/15878708.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e29d024822df85f1aa0b737bb4123c869646d737c15bf05f1dc72b047a45eef3\", \"start_char\": 0, \"end_char\": 1966, \"text_sha256\": \"e29d024822df85f1aa0b737bb4123c869646d737c15bf05f1dc72b047a45eef3\"}\n[mangiferin-p15878708] Iron complexing activity of mangiferin, a naturally occurring glucosylxanthone, inhibits mitochondrial lipid peroxidation induced by Fe2+-citrate. 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