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10 mM LiCl versus matched NaCl.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"High experimental exposure; knockout occlusion supports a pathway but does not prove clinical cartilage damage.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"The lithium response depended on this Golgi enzyme.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Sulfation of glycosaminoglycans depends on the catalytic activity of lithium-inhibited phosphatase BPNT2 in vitro. · 2021 · https://pubmed.ncbi.nlm.nih.gov/34634304/ · DOI 10.1016/j.jbc.2021.101293","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b707dff3-9a66-57df-874e-1a6eb4da0a77","evidence_kind":"source_excerpt","locator":"Lines 160-166","start_line":160,"end_line":166,"excerpt":"## lithium-bpnt2-lithium-gag\nThe lithium response depended on this Golgi enzyme.\nLiCl reduced intracellular and secreted GAG sulfation in wild-type mouse fibroblasts, with no further reduction after Bpnt2 knockout.\nModel: Mouse embryonic fibroblasts; 10 mM LiCl versus matched NaCl.\nLimitations: High experimental exposure; knockout occlusion supports a pathway but does not prove clinical cartilage damage.\nEvidence access: Primary full text\nSulfation of glycosaminoglycans depends on the catalytic activity of lithium-inhibited phosphatase BPNT2 in vitro. · 2021 · https://pubmed.ncbi.nlm.nih.gov/34634304/ · DOI 10.1016/j.jbc.2021.101293","model_system":"Mouse embryonic fibroblasts; 10 mM LiCl versus matched NaCl.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b2dd2f3c-5c4c-5a12-9a0d-91b521ffcf98","stable_key":"import-b7798a90-72a3-5454-a321-c4be88bf0cc4","title":"Lithium: metal-sensitive enzymes, transport and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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