{"id":"9e91ed6b-3cf1-5849-bd68-b02683f9a359","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-checkpoint-rna","predicate":"supports_tested","statement":"Methionine-derived SAM supported m6A modification and YTHDF1-associated translation of PD-L1 and VISTA transcripts in the tumor study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"43a636e2-9c4c-58c9-a76e-bcbd06fdacf6","mechanism_event_label":"The same donor can support an immune-evasion pathway in a different cell.","subject":{"id":"825f2da2-01bc-5874-a3c6-64f5ac867db5","slug":"s-adenosylmethionine","display_name":"S-Adenosyl-L-methionine","entity_type_key":"small_molecule"},"object":{"id":"7ee0b395-5d92-5b5c-aacf-ada4ef5761f2","slug":"tumor-checkpoint-m6a-translation","display_name":"m6A-dependent immune-checkpoint translation in tumor models","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"43a636e2-9c4c-58c9-a76e-bcbd06fdacf6","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-checkpoint-rna-event","event_type":"observed_relationship","label":"The same donor can support an immune-evasion pathway in a different cell.","description":"Methionine-derived SAM supported m6A modification and YTHDF1-associated translation of PD-L1 and VISTA transcripts in the tumor study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"825f2da2-01bc-5874-a3c6-64f5ac867db5","slug":"s-adenosylmethionine","display_name":"S-Adenosyl-L-methionine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7ee0b395-5d92-5b5c-aacf-ada4ef5761f2","slug":"tumor-checkpoint-m6a-translation","display_name":"m6A-dependent immune-checkpoint translation in tumor models","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9d39f561-740b-5f67-bba7-8a72ef612a99","slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"2576cef2-5557-5ce4-9382-22f52cc099fd","slug":"tumor-study-ythdf1","display_name":"YTHDF1 in the tumor study, species unresolved here","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Tumor-cell and mouse experiments; construct species unresolved in accessed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not mean all methionine methylation suppresses immunity.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Methionine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The same donor can support an immune-evasion pathway in a different cell.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Methionine deficiency facilitates antitumour immunity by altering m6A methylation of immune checkpoint transcripts. · 2023 · https://pubmed.ncbi.nlm.nih.gov/35803704/ · DOI 10.1136/gutjnl-2022-326928","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"21d47579-5fa6-5a01-91a5-6cfc701b66a6","evidence_kind":"source_excerpt","locator":"Lines 444-450","start_line":444,"end_line":450,"excerpt":"## methionine-checkpoint-rna\nThe same donor can support an immune-evasion pathway in a different cell.\nMethionine-derived SAM supported m6A modification and YTHDF1-associated translation of PD-L1 and VISTA transcripts in the tumor study.\nModel: Tumor-cell and mouse experiments; construct species unresolved in accessed abstract.\nLimitations: Does not mean all methionine methylation suppresses immunity.\nEvidence access: Primary abstract\nMethionine deficiency facilitates antitumour immunity by altering m6A methylation of immune checkpoint transcripts. · 2023 · https://pubmed.ncbi.nlm.nih.gov/35803704/ · DOI 10.1136/gutjnl-2022-326928","model_system":"Tumor-cell and mouse experiments; construct species unresolved in accessed abstract.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"d969b004-ccc2-5bb4-9109-8ac649137ad1","stable_key":"import-41a89233-da9a-5b7b-9c18-e19bbadcfe2d","title":"L-Methionine: transport, methylation, sulfur metabolism and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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