{"id":"9e80b019-efcc-549c-8660-7876c6b226fc","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-gabaa-tonic","predicate":"activates","statement":"Taurine at 10–100 micromolar reduced excitability of mouse thalamocortical neurons and evoked tonic currents consistent with extrasynaptic alpha4beta2delta GABA-A receptors.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5fec3ec5-6492-5d0a-a488-9d44e409f621","mechanism_event_label":"A low concentration changed neuronal firing in this mouse brain region.","subject":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"object":{"id":"04a65277-f6fc-51c4-85e8-6de07891530c","slug":"mouse-gabaa-alpha4beta2delta","display_name":"Mouse extrasynaptic alpha4beta2delta GABA-A receptor","entity_type_key":"protein_complex"},"evidence_count":1,"mechanism_event":{"id":"5fec3ec5-6492-5d0a-a488-9d44e409f621","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-gabaa-tonic-event","event_type":"observed_relationship","label":"A low concentration changed neuronal firing in this mouse brain region.","description":"Taurine at 10–100 micromolar reduced excitability of mouse thalamocortical neurons and evoked tonic currents consistent with extrasynaptic alpha4beta2delta GABA-A receptors.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"04a65277-f6fc-51c4-85e8-6de07891530c","slug":"mouse-gabaa-alpha4beta2delta","display_name":"Mouse extrasynaptic alpha4beta2delta GABA-A receptor","entity_type_key":"protein_complex"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6f35aa38-f875-5759-b749-97a2f6480ff3","slug":"chloride-ion","display_name":"Chloride ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse ventrobasal thalamic neurons and recombinant receptor comparisons.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Bath concentration is not an oral dose; this does not establish treatment of human anxiety or insomnia.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A low concentration changed neuronal firing in this mouse brain region.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Taurine is a potent activator of extrasynaptic GABA(A) receptors in the thalamus. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18171928/ · DOI 10.1523/JNEUROSCI.3996-07.2008","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"dd78c50e-66aa-5794-a4d3-f1de7c158b21","evidence_kind":"source_excerpt","locator":"Lines 433-439","start_line":433,"end_line":439,"excerpt":"## taurine-gabaa-tonic\nA low concentration changed neuronal firing in this mouse brain region.\nTaurine at 10–100 micromolar reduced excitability of mouse thalamocortical neurons and evoked tonic currents consistent with extrasynaptic alpha4beta2delta GABA-A receptors.\nModel: Mouse ventrobasal thalamic neurons and recombinant receptor comparisons.\nLimitations: Bath concentration is not an oral dose; this does not establish treatment of human anxiety or insomnia.\nEvidence access: Primary abstract\nTaurine is a potent activator of extrasynaptic GABA(A) receptors in the thalamus. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18171928/ · DOI 10.1523/JNEUROSCI.3996-07.2008","model_system":"Mouse ventrobasal thalamic neurons and recombinant receptor comparisons.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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