{"id":"9e7493d3-e891-535e-a4a3-932b6f4c5f27","stable_key":"220adaab-10d8-5c4e-a3f5-a48700ea794d:agmatine-sulfate-cds-specificity","predicate":"does_not_fully_explain","statement":"Agmatine and endogenous bovine hypothalamic clonidine-displacing material had different affinity rankings across the tested receptor panel.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"66c927e3-a250-5fdd-b4d2-e32a5b3e6edb","mechanism_event_label":"An extract containing an active compound can have additional active constituents.","subject":{"id":"e2f83eb4-99ed-5050-87d3-3e4701d05c1a","slug":"agmatine","display_name":"Agmatine","entity_type_key":"small_molecule"},"object":{"id":"bff4efc2-455f-5571-888a-50950ae12fa1","slug":"bovine-hypothalamic-clonidine-displacing-profile","display_name":"Bovine hypothalamic clonidine-displacing-substance binding profile","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"66c927e3-a250-5fdd-b4d2-e32a5b3e6edb","stable_key":"220adaab-10d8-5c4e-a3f5-a48700ea794d:agmatine-sulfate-cds-specificity-event","event_type":"observed_relationship","label":"An extract containing an active compound can have additional active constituents.","description":"Agmatine and endogenous bovine hypothalamic clonidine-displacing material had different affinity rankings across the tested receptor panel.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e2f83eb4-99ed-5050-87d3-3e4701d05c1a","slug":"agmatine","display_name":"Agmatine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"bff4efc2-455f-5571-888a-50950ae12fa1","slug":"bovine-hypothalamic-clonidine-displacing-profile","display_name":"Bovine hypothalamic clonidine-displacing-substance binding profile","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ae2dddf4-ce04-57e3-8a06-7ed9fdc24554","slug":"agmatine-sulfate","display_name":"Agmatine Sulfate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human and bovine receptor preparations with purified compound and endogenous extract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This qualifies the identity of the extract; it does not negate agmatine binding.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Agmatine Sulfate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"agmatine-sulfate","display_name":"Agmatine Sulfate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"An extract containing an active compound can have additional active constituents.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Comparison of the properties of agmatine and endogenous clonidine-displacing substance at imidazoline and alpha-2 adrenergic receptors. · 1995 · https://pubmed.ncbi.nlm.nih.gov/7853171/","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0824c4dc-5015-5a50-b850-8b33fe56fbab","evidence_kind":"source_excerpt","locator":"Lines 316-322","start_line":316,"end_line":322,"excerpt":"## agmatine-sulfate-cds-specificity\nAn extract containing an active compound can have additional active constituents.\nAgmatine and endogenous bovine hypothalamic clonidine-displacing material had different affinity rankings across the tested receptor panel.\nModel: Human and bovine receptor preparations with purified compound and endogenous extract.\nLimitations: This qualifies the identity of the extract; it does not negate agmatine binding.\nEvidence access: Primary abstract\nComparison of the properties of agmatine and endogenous clonidine-displacing substance at imidazoline and alpha-2 adrenergic receptors. · 1995 · https://pubmed.ncbi.nlm.nih.gov/7853171/","model_system":"Human and bovine receptor preparations with purified compound and endogenous extract.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e0426971-7d13-51c9-8354-6547b664f1cf","stable_key":"import-220adaab-10d8-5c4e-a3f5-a48700ea794d","title":"Agmatine Sulfate: transport, guanidino metabolism, ion channels and cross-nutrient mechanisms (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b55d70e22d07b80964f825770d92fdd1745221420ed8af8d94ca5182b9994509","revision_id":"fc7be029-20e0-5943-b74e-3b06ba694571","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}