{"id":"9df0331f-638b-5e64-bf3a-d9867842a486","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-cud-sensory-ataxia","predicate":"associated_with","statement":"All six patients had prominent gait impairment from sensory ataxia.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"bdb74f60-df7d-536e-8e4b-725351eac35b","mechanism_event_label":"Loss of position-sense signaling can make walking unstable.","subject":{"id":"0e80b8b7-e6f7-5831-b047-2a264f37dd42","slug":"copper-deficiency-myeloneuropathy","display_name":"Myeloneuropathy associated with copper deficiency","entity_type_key":"cellular_process"},"object":{"id":"3a991ab3-d544-5229-9487-35fa8aff6a57","slug":"sensory-ataxia","display_name":"Sensory ataxia","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"bdb74f60-df7d-536e-8e4b-725351eac35b","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-cud-sensory-ataxia-event","event_type":"observed_intervention","label":"Loss of position-sense signaling can make walking unstable.","description":"All six patients had prominent gait impairment from sensory ataxia.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0e80b8b7-e6f7-5831-b047-2a264f37dd42","slug":"copper-deficiency-myeloneuropathy","display_name":"Myeloneuropathy associated with copper deficiency","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3a991ab3-d544-5229-9487-35fa8aff6a57","slug":"sensory-ataxia","display_name":"Sensory ataxia","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/copper-research/18495738.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0869f1a2ef3e333451666857ce5f005a08028c0fec6b384dce5fa69b4ae15644\", \"start_char\": 0, \"end_char\": 1153, \"text_sha256\": \"0869f1a2ef3e333451666857ce5f005a08028c0fec6b384dce5fa69b4ae15644\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Clinical neurophysiology case series","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Six patients with copper-deficiency myeloneuropathy","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small case series; does not identify one causal cuproenzyme or establish that B12 deficiency caused the syndrome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Copper research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Loss of position-sense signaling can make walking unstable.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[copper-p18495738] Clinical and electrodiagnostic findings in copper deficiency myeloneuropathy. (2009). https://pubmed.ncbi.nlm.nih.gov/18495738/ DOI: 10.1136/jnnp.2008.144683","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Peripheral and central sensory pathways","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"2ac49852-3407-5c8e-8606-f4c8a326663f","evidence_kind":"source_excerpt","locator":"Lines 1417-1428","start_line":1417,"end_line":1428,"excerpt":"### copper-cud-sensory-ataxia\nAll six patients had prominent gait impairment from sensory ataxia.\nCondition category: nutrient_deficiency\nnutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Loss of position-sense signaling can make walking unstable.\norganism: Human\ntissue_or_cell_type: Peripheral and central sensory pathways\nexperimental_model: Clinical neurophysiology case series\nlimitations: Small case series; does not identify one causal cuproenzyme or establish that B12 deficiency caused the syndrome.\nexposure: Six patients with copper-deficiency myeloneuropathy\nevidence_span: {\"source_cache\": \"artifacts/copper-research/18495738.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0869f1a2ef3e333451666857ce5f005a08028c0fec6b384dce5fa69b4ae15644\", \"start_char\": 0, \"end_char\": 1153, \"text_sha256\": \"0869f1a2ef3e333451666857ce5f005a08028c0fec6b384dce5fa69b4ae15644\"}\n[copper-p18495738] Clinical and electrodiagnostic findings in copper deficiency myeloneuropathy. 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