{"id":"9dc8a803-21d8-53fe-896e-cc2f195df5c2","stable_key":"792249b7-a38d-5f43-afb6-2936818a3fa2:tartrazine-scap-product","predicate":"is_reduced_to","statement":"The reduced tartrazine pyrazole product SCAP was chemically identified.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"eb0c54b9-5cd6-5f41-a174-9a96126d1487","mechanism_event_label":"The reduced tartrazine pyrazole product SCAP was chemically identified.","subject":{"id":"135b5f4d-0c59-5359-a645-39796e820d42","slug":"tartrazine","display_name":"Tartrazine","entity_type_key":"small_molecule"},"object":{"id":"6f240462-6ef8-5755-8bfe-04d2cc5c1f1b","slug":"tartrazine-scap","display_name":"SCAP: reduced pyrazole metabolite of tartrazine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"eb0c54b9-5cd6-5f41-a174-9a96126d1487","stable_key":"792249b7-a38d-5f43-afb6-2936818a3fa2:tartrazine-scap-product-event","event_type":"observed_relationship","label":"The reduced tartrazine pyrazole product SCAP was chemically identified.","description":"The reduced tartrazine pyrazole product SCAP was chemically identified.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"135b5f4d-0c59-5359-a645-39796e820d42","slug":"tartrazine","display_name":"Tartrazine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6f240462-6ef8-5755-8bfe-04d2cc5c1f1b","slug":"tartrazine-scap","display_name":"SCAP: reduced pyrazole metabolite of tartrazine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Tartrazine/isolated metabolites; preparative concentrations not recovered from primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Reaction intervals not recovered from accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract; unrecovered method details explicitly retained.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; source-specific experimental curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human-stool bacterial isolates and analytical chemistry of tartrazine products","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"SCAP and PPA identities were experimentally characterized. The additional yellow derivative remains proposed and is not imported as an established metabolite. Human circulating exposure was not measured.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Tartrazine food-colorant chapter; nutrient, drug and peptide interactions retain their models and limits.","comparator":null,"unit":null,"notes":"","entity":{"slug":"tartrazine","display_name":"Tartrazine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human-stool bacterial isolates and analytical chemistry of tartrazine products","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The reduced tartrazine pyrazole product SCAP was chemically identified.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Preparation, analysis and toxicity characterisation of the redox metabolites of the azo food dye tartrazine. (2023). https://pubmed.ncbi.nlm.nih.gov/37980979/ DOI: 10.1016/j.fct.2023.114193","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro biotransformation and chemical characterization","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Azo reduction followed by oxidation on exposure to air","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d218c654-d063-54ad-8907-14eb150f4dc2","evidence_kind":"source_excerpt","locator":"Lines 94-103","start_line":94,"end_line":103,"excerpt":"## tartrazine-scap-product\nThe reduced tartrazine pyrazole product SCAP was chemically identified.\nModel/species: Human-stool bacterial isolates and analytical chemistry of tartrazine products\nTissue: Azo reduction followed by oxidation on exposure to air\nExposure: Tartrazine/isolated metabolites; preparative concentrations not recovered from primary abstract\nRoute: In vitro biotransformation and chemical characterization\nDuration: Reaction intervals not recovered from accessed abstract\nLimits: SCAP and PPA identities were experimentally characterized. The additional yellow derivative remains proposed and is not imported as an established metabolite. Human circulating exposure was not measured.\nPrimary reference: Preparation, analysis and toxicity characterisation of the redox metabolites of the azo food dye tartrazine. (2023). https://pubmed.ncbi.nlm.nih.gov/37980979/ DOI: 10.1016/j.fct.2023.114193\nAccess: Primary PubMed abstract; unrecovered method details explicitly retained.","model_system":"Human-stool bacterial isolates and analytical chemistry of tartrazine products","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span, not a publisher quotation; primary citation retained.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"d9540941-68b4-5a0d-a5c1-828665a918e2","stable_key":"import-792249b7-a38d-5f43-afb6-2936818a3fa2","title":"Tartrazine: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of eighteen primary studies. Study-specific citations, negative findings and limitations retained. Not publisher full text.","file_path":"","sha256":"b83a0113a4b743adc91c24504e488f47e10665386b299c4cb0543da8948f4246","revision_id":"3769070e-6af4-5b02-9d8e-f23c84edba1b","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}