{"id":"9d87c9b1-4b52-59d5-83e9-cc4bdc287b01","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-ra-cointervention-cytokine-signal","predicate":"accompanied_within_group_cytokine_decline","statement":"In the 2010 cointervention trial, plasma IL-6 and TNF declined within the B6-plus-folic-acid group over 12 weeks.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"f0588a69-f01f-53ea-93f2-65128a014c6b","mechanism_event_label":"A different trial found a cytokine signal under a different exposure and measurement design.","subject":{"id":"c0beb226-8842-501f-a147-cac0d9fa7060","slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"},"object":{"id":"ef8f8807-395d-5dc6-9693-70e90f41b268","slug":"il6","display_name":"IL6","entity_type_key":"cytokine"},"evidence_count":1,"mechanism_event":{"id":"f0588a69-f01f-53ea-93f2-65128a014c6b","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-ra-cointervention-cytokine-signal-event","event_type":"observed_intervention","label":"A different trial found a cytokine signal under a different exposure and measurement design.","description":"In the 2010 cointervention trial, plasma IL-6 and TNF declined within the B6-plus-folic-acid group over 12 weeks.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"600d5b09-e092-5146-af1e-2510cf17bac6","slug":"tnf","display_name":"Tumor necrosis factor","entity_type_key":"cytokine"},"role":"measured_cytokine","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d322bfef-5135-599f-82e6-0aa58748dc8b","slug":"folic-acid","display_name":"Folic acid","entity_type_key":"small_molecule"},"role":"cointervention","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c0beb226-8842-501f-a147-cac0d9fa7060","slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"ef8f8807-395d-5dc6-9693-70e90f41b268","slug":"il6","display_name":"IL6","entity_type_key":"cytokine"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Folic acid was given to both arms; no biochemical B6–folate synergy established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Single-blind randomized cointervention in 35 RA patients: 15 control and 20 B6.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Both groups folic acid 5 mg/day; B6 group also 100 mg/day for 12 weeks. Reported cytokine result is within-group change.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The accessed abstract reports within-group significance, not a demonstrated between-group change contrast. Plasma concentration differs from cytokine production; no automatic contradiction with 2005.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A different trial found a cytokine signal under a different exposure and measurement design.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b6-huang2010] Vitamin B(6) supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis (2010). https://pubmed.ncbi.nlm.nih.gov/20571496/ DOI: 10.1038/ejcn.2010.107","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human blood and whole-body measurements","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2dfe36c5-bd11-5484-99fc-f9ca3f0c30e7","evidence_kind":"source_excerpt","locator":"Lines 1510-1521","start_line":1510,"end_line":1521,"excerpt":"### b6-ra-cointervention-cytokine-signal\nIn the 2010 cointervention trial, plasma IL-6 and TNF declined within the B6-plus-folic-acid group over 12 weeks.\nCondition category: normal\nnutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A different trial found a cytokine signal under a different exposure and measurement design.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood and whole-body measurements\nexperimental_model: Single-blind randomized cointervention in 35 RA patients: 15 control and 20 B6.\nlimitations: The accessed abstract reports within-group significance, not a demonstrated between-group change contrast. Plasma concentration differs from cytokine production; no automatic contradiction with 2005.\nexposure: Both groups folic acid 5 mg/day; B6 group also 100 mg/day for 12 weeks. Reported cytokine result is within-group change.\ncross_nutrient: Folic acid was given to both arms; no biochemical B6–folate synergy established.\n[b6-huang2010] Vitamin B(6) supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis (2010). https://pubmed.ncbi.nlm.nih.gov/20571496/ DOI: 10.1038/ejcn.2010.107","model_system":"Single-blind randomized cointervention in 35 RA patients: 15 control and 20 B6.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b6-huang2010] Vitamin B(6) supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis (2010). https://pubmed.ncbi.nlm.nih.gov/20571496/ DOI: 10.1038/ejcn.2010.107","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"251773bb-16f5-5903-b135-db4a61d9dec4","stable_key":"import-1310afbd-6010-586e-805d-551d846da421","title":"Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ef0019b344b2219220f801a84d0d138ff6880c1be1a59540d9034bfa4334f61e","revision_id":"cac3555f-48af-5c52-a84e-add4482c87fb","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}