{"id":"9d4be94e-6c96-58a0-aa5b-4bc4f9a4c97a","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-fluvox-clear","predicate":"reduces","statement":"Median caffeine clearance fell from 107 to 21 mL/min during fluvoxamine treatment.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"85998bfa-c2d5-5c51-b99a-09038c22a298","mechanism_event_label":"Inhibiting the metabolic pathway slowed caffeine removal.","subject":{"id":"df26c2cc-f2ee-543e-81ce-7a332fe3b644","slug":"fluvoxamine","display_name":"Fluvoxamine","entity_type_key":"small_molecule"},"object":{"id":"a7ade0b8-199b-542e-b9be-c8ad2c2b68c1","slug":"caffeine-clearance","display_name":"Caffeine clearance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"85998bfa-c2d5-5c51-b99a-09038c22a298","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-fluvox-clear-event","event_type":"observed_relationship","label":"Inhibiting the metabolic pathway slowed caffeine removal.","description":"Median caffeine clearance fell from 107 to 21 mL/min during fluvoxamine treatment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"df26c2cc-f2ee-543e-81ce-7a332fe3b644","slug":"fluvoxamine","display_name":"Fluvoxamine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a7ade0b8-199b-542e-b9be-c8ad2c2b68c1","slug":"caffeine-clearance","display_name":"Caffeine clearance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9b15c13c-a369-5d10-a76a-525e8b19221d","slug":"cyp1a2","display_name":"Human cytochrome P450 1A2","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human caffeine/fluvoxamine crossover and metabolite measurements; eight healthy volunteers.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Study used 200 mg caffeine and repeated fluvoxamine; not a prediction of the same effect size for every CYP1A2 inhibitor.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Caffeine collection; salts, coffee, species and coexposure contexts retain their identities.","comparator":null,"unit":null,"notes":"","entity":{"slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Inhibiting the metabolic pathway slowed caffeine removal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"A fluvoxamine-caffeine interaction study. · 1996 · https://pubmed.ncbi.nlm.nih.gov/8807660/ · DOI 10.1097/00008571-199606000-00003","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5ddb191d-1154-57b3-95ec-c1a33542bfdd","evidence_kind":"source_excerpt","locator":"Lines 196-202","start_line":196,"end_line":202,"excerpt":"## caf-fluvox-clear\nInhibiting the metabolic pathway slowed caffeine removal.\nMedian caffeine clearance fell from 107 to 21 mL/min during fluvoxamine treatment.\nModel: Human caffeine/fluvoxamine crossover and metabolite measurements; eight healthy volunteers.\nLimitations: Study used 200 mg caffeine and repeated fluvoxamine; not a prediction of the same effect size for every CYP1A2 inhibitor.\nEvidence access: Primary abstract\nA fluvoxamine-caffeine interaction study. · 1996 · https://pubmed.ncbi.nlm.nih.gov/8807660/ · DOI 10.1097/00008571-199606000-00003","model_system":"Human caffeine/fluvoxamine crossover and metabolite measurements; eight healthy volunteers.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access stated with the claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"40a654db-878c-5471-bc6c-88f4f52599c0","stable_key":"import-ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6","title":"Caffeine: receptors, metabolism, nutrient interactions, adaptation and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"780d73d4abd45a0284d2cc0c646dbe8432ae347362891a4b98a19a61341a7325","revision_id":"f36ffb0a-d6df-522f-b783-5e30214b9e26","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}