{"id":"9d0a747e-fc7c-51d1-b0c9-bc050c609887","stable_key":"507ed066-fd6d-5722-9223-97b66302e7e3:glycine-s38-glycine-transport","predicate":"transports_tested","statement":"The biochemical characterization reported glycine transport by human SLC25A38; human SLC25A38 expression complemented heme-pathway defects in yeast lacking Hem25.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d9a9c300-a1ae-5433-a9c8-9adf83d8c3ea","mechanism_event_label":"A mitochondrial carrier connects access to glycine with heme production.","subject":{"id":"4e146c00-9b97-55d6-ac1c-0a0261378be3","slug":"slc25a38","display_name":"Human SLC25A38","entity_type_key":"protein"},"object":{"id":"2b507258-430c-51fe-9fd2-e510c2c197a9","slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"d9a9c300-a1ae-5433-a9c8-9adf83d8c3ea","stable_key":"507ed066-fd6d-5722-9223-97b66302e7e3:glycine-s38-glycine-transport-event","event_type":"observed_relationship","label":"A mitochondrial carrier connects access to glycine with heme production.","description":"The biochemical characterization reported glycine transport by human SLC25A38; human SLC25A38 expression complemented heme-pathway defects in yeast lacking Hem25.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4e146c00-9b97-55d6-ac1c-0a0261378be3","slug":"slc25a38","display_name":"Human SLC25A38","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2b507258-430c-51fe-9fd2-e510c2c197a9","slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human/yeast carrier biochemistry and yeast genetic complementation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Primary abstract access; later PLP-homeostasis findings broaden interpretation. This claim does not establish exclusive substrate specificity.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Glycine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A mitochondrial carrier connects access to glycine with heme production.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Characterization of Human and Yeast Mitochondrial Glycine Carriers with Implications for Heme Biosynthesis and Anemia. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27476175/ · DOI 10.1074/jbc.M116.736876","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"transport_effect","value_text":"raises","comparator":null,"unit":null,"notes":"Human expression complemented heme-pathway defects in yeast lacking Hem25, which is matrix glycine supply.","entity":null},{"dimension":"transport_pool","value_text":"the mitochondrial matrix","comparator":null,"unit":null,"notes":"Human expression complemented heme-pathway defects in yeast lacking Hem25, which is matrix glycine supply.","entity":null}],"evidence":[{"id":"604ee6b6-483c-5532-b3f2-4a6b5281c561","evidence_kind":"source_excerpt","locator":"Lines 82-88","start_line":82,"end_line":88,"excerpt":"## glycine-s38-glycine-transport\nA mitochondrial carrier connects access to glycine with heme production.\nThe biochemical characterization reported glycine transport by human SLC25A38; human SLC25A38 expression complemented heme-pathway defects in yeast lacking Hem25.\nModel: Human/yeast carrier biochemistry and yeast genetic complementation.\nLimitations: Primary abstract access; later PLP-homeostasis findings broaden interpretation. This claim does not establish exclusive substrate specificity.\nEvidence access: Primary abstract\nCharacterization of Human and Yeast Mitochondrial Glycine Carriers with Implications for Heme Biosynthesis and Anemia. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27476175/ · DOI 10.1074/jbc.M116.736876","model_system":"Human/yeast carrier biochemistry and yeast genetic complementation.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"7b2859d8-e2bf-51e7-8e32-0715c10cbc49","stable_key":"import-507ed066-fd6d-5722-9223-97b66302e7e3","title":"Glycine: supply, one-carbon allocation, receptors and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"4fabd2fc8e71ca156c91023e7340be3f5a02ae03e91d3a24b231c2adfb0de0aa","revision_id":"24801e49-34a8-53c3-bdf5-b59143441450","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}