{"id":"9cfa09bf-373d-5440-a6c2-537eca2d05b5","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-skin-uv","predicate":"increases","statement":"A small randomized study in 23 healthy Japanese participants found a higher minimal erythema dose and less UV-related moisture loss with 4 mg/day astaxanthin.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d85ab0aa-8d1e-52b1-83a2-dcee46a22c96","mechanism_event_label":"Skin response to a controlled UV challenge changed.","subject":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"object":{"id":"c1490e8b-56ab-58e8-8376-dd3d357ca6c2","slug":"human-astaxanthin-uv-erythema","display_name":"Human minimal UV erythema dose after astaxanthin","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d85ab0aa-8d1e-52b1-83a2-dcee46a22c96","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-skin-uv-event","event_type":"observed_relationship","label":"Skin response to a controlled UV challenge changed.","description":"A small randomized study in 23 healthy Japanese participants found a higher minimal erythema dose and less UV-related moisture loss with 4 mg/day astaxanthin.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c1490e8b-56ab-58e8-8376-dd3d357ca6c2","slug":"human-astaxanthin-uv-erythema","display_name":"Human minimal UV erythema dose after astaxanthin","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Ten-week study; UV assessment after approximately nine weeks.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small sponsor-associated study; not proof of skin-cancer prevention or a replacement for sunscreen.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Skin response to a controlled UV challenge changed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The Protective Role of Astaxanthin for UV-Induced Skin Deterioration in Healthy People-A Randomized, Double-Blind, Placebo-Controlled Trial. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29941810/ · DOI 10.3390/nu10070817","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ff62d6b4-29ec-5403-af95-2138e0371e46","evidence_kind":"source_excerpt","locator":"Lines 406-412","start_line":406,"end_line":412,"excerpt":"## astaxanthin-skin-uv\nSkin response to a controlled UV challenge changed.\nA small randomized study in 23 healthy Japanese participants found a higher minimal erythema dose and less UV-related moisture loss with 4 mg/day astaxanthin.\nModel: Ten-week study; UV assessment after approximately nine weeks.\nLimitations: Small sponsor-associated study; not proof of skin-cancer prevention or a replacement for sunscreen.\nEvidence access: Primary abstract\nThe Protective Role of Astaxanthin for UV-Induced Skin Deterioration in Healthy People-A Randomized, Double-Blind, Placebo-Controlled Trial. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29941810/ · DOI 10.3390/nu10070817","model_system":"Ten-week study; UV assessment after approximately nine weeks.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"98640e32f62e6c0387578165342ad21b3d2325701fcfdbb5c48886c783040e5e","revision_id":"a82757ce-1feb-582c-a5fc-f7de36308f1f","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}