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(2016). https://pubmed.ncbi.nlm.nih.gov/27636860/ DOI: 10.1080/01635581.2016.1224369","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Nrf2 targets and cell defense","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"beb15487-7620-587d-be48-ec286a5498ae","evidence_kind":"source_excerpt","locator":"Lines 541-552","start_line":541,"end_line":552,"excerpt":"### sulforaphane-nqo1-induction\nSulforaphane induced Nrf2-dependent NQO1 expression in untransformed human CRL-1790 colon cells.\nCondition category: normal\nnutrient_topic: Sulforaphane research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: One induced enzyme handles quinone chemistry.\norganism: Human CRL-1790 untransformed colon cells, HT-29 and Caco-2 cancer cells\ntissue_or_cell_type: Nrf2 targets and cell defense\nexperimental_model: Gene and enzyme-response comparison\nlimitations: Cancer and untransformed cells regulated the pathway differently; no claim that all Nrf2 activation is desirable in established tumors.\nexposure: Sulforaphane exposure across three cell contexts\nevidence_span: {\"source_cache\": \"artifacts/sulforaphane-research/27636860.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"38b05ba233878d75f74373f3093e4d51bbbbb417b59f06dec578f7c293e12793\", \"start_char\": 0, \"end_char\": 1177, \"text_sha256\": \"38b05ba233878d75f74373f3093e4d51bbbbb417b59f06dec578f7c293e12793\"}\n[sulforaphane-p27636860] Sulforaphane Regulates NFE2L2/Nrf2-Dependent Xenobiotic Metabolism Phase II and Phase III Enzymes Differently in Human Colorectal Cancer and Untransformed Epithelial Colon Cells. 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