{"id":"9cd3b638-e71a-5dec-af8e-5632c31a32ee","stable_key":"53d9b98d-e3a0-5416-bc88-adbe42a8cb1b:curcumin-liver-injury","predicate":"associated_with","statement":"Ten adjudicated cases included nine hepatocellular injuries; five patients were hospitalized and one died.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6409601a-6bf9-55a1-96c4-ba5a5c97e77b","mechanism_event_label":"Serious liver injury was documented with implicated turmeric supplements.","subject":{"id":"b252a44a-df6e-5aa3-870c-76ba853aef78","slug":"turmeric-supplement-products","display_name":"Turmeric supplement products, case-specific composition","entity_type_key":"chemical_species"},"object":{"id":"43b365f8-b6f1-5045-bed9-98e10402c6a5","slug":"turmeric-associated-liver-injury","display_name":"Adjudicated turmeric-supplement-associated liver injury","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6409601a-6bf9-55a1-96c4-ba5a5c97e77b","stable_key":"53d9b98d-e3a0-5416-bc88-adbe42a8cb1b:curcumin-liver-injury-event","event_type":"observed_intervention","label":"Serious liver injury was documented with implicated turmeric supplements.","description":"Ten adjudicated cases included nine hepatocellular injuries; five patients were hospitalized and one died.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b252a44a-df6e-5aa3-870c-76ba853aef78","slug":"turmeric-supplement-products","display_name":"Turmeric supplement products, case-specific composition","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"43b365f8-b6f1-5045-bed9-98e10402c6a5","slug":"turmeric-associated-liver-injury","display_name":"Adjudicated turmeric-supplement-associated liver injury","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/curcumin-research/36252717.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"f5f0d7db2b11e9ba6d176c45671428ac43c57cd8ce447873ea5fecd0d554244c\", \"start_char\": 0, \"end_char\": 1722, \"text_sha256\": \"f5f0d7db2b11e9ba6d176c45671428ac43c57cd8ce447873ea5fecd0d554244c\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Expert-adjudicated DILIN case series with product testing and HLA typing","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Ten cases associated with turmeric supplements; seven available products tested, three contained piperine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Case series cannot estimate incidence, assign every case to purified curcumin or establish that piperine caused the injury. HLA association is not a sufficient diagnostic test.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Curcumin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"curcumin","display_name":"Curcumin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Serious liver injury was documented with implicated turmeric supplements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[curcumin-p36252717] Liver Injury Associated with Turmeric-A Growing Problem: Ten Cases from the Drug-Induced Liver Injury Network [DILIN]. (2023). https://pubmed.ncbi.nlm.nih.gov/36252717/ DOI: 10.1016/j.amjmed.2022.09.026","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Liver injury","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a143dee4-b7cd-5509-a546-90a7d80f400e","evidence_kind":"source_excerpt","locator":"Lines 1126-1137","start_line":1126,"end_line":1137,"excerpt":"### curcumin-liver-injury\nTen adjudicated cases included nine hepatocellular injuries; five patients were hospitalized and one died.\nCondition category: normal\nnutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Serious liver injury was documented with implicated turmeric supplements.\norganism: Homo sapiens\ntissue_or_cell_type: Liver injury\nexperimental_model: Expert-adjudicated DILIN case series with product testing and HLA typing\nlimitations: Case series cannot estimate incidence, assign every case to purified curcumin or establish that piperine caused the injury. HLA association is not a sufficient diagnostic test.\nexposure: Ten cases associated with turmeric supplements; seven available products tested, three contained piperine\nevidence_span: {\"source_cache\": \"artifacts/curcumin-research/36252717.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"f5f0d7db2b11e9ba6d176c45671428ac43c57cd8ce447873ea5fecd0d554244c\", \"start_char\": 0, \"end_char\": 1722, \"text_sha256\": \"f5f0d7db2b11e9ba6d176c45671428ac43c57cd8ce447873ea5fecd0d554244c\"}\n[curcumin-p36252717] Liver Injury Associated with Turmeric-A Growing Problem: Ten Cases from the Drug-Induced Liver Injury Network [DILIN]. (2023). https://pubmed.ncbi.nlm.nih.gov/36252717/ DOI: 10.1016/j.amjmed.2022.09.026","model_system":"Expert-adjudicated DILIN case series with product testing and HLA typing","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [curcumin-p36252717] Liver Injury Associated with Turmeric-A Growing Problem: Ten Cases from the Drug-Induced Liver Injury Network [DILIN]. (2023). https://pubmed.ncbi.nlm.nih.gov/36252717/ DOI: 10.1016/j.amjmed.2022.09.026","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"11d29ea9-3af1-5404-a68d-6f129e23edee","stable_key":"import-53d9b98d-e3a0-5416-bc88-adbe42a8cb1b","title":"Curcumin: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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