{"id":"9cb21d03-ad0e-57a7-9c84-6836e52be3c4","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-foxo3-loss","predicate":"deletion_blunts","statement":"Foxo3 deletion, unlike Foxo1 deletion, made mouse stem/progenitor cells resistant to butyrate-mediated proliferation suppression.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6594a2e3-d836-548f-ab58-3822bddbdc2e","mechanism_event_label":"The growth-suppressing response depended on a specific transcription factor.","subject":{"id":"e003cfb7-f795-582d-a3d1-6a0b8fd95151","slug":"mouse-foxo3","display_name":"Mouse forkhead transcription factor Foxo3","entity_type_key":"protein"},"object":{"id":"3f0b9f24-c335-5642-91b8-13e4d47f904f","slug":"mouse-crypt-stem-proliferation","display_name":"Mouse colonic stem/progenitor-cell proliferation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6594a2e3-d836-548f-ab58-3822bddbdc2e","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-foxo3-loss-event","event_type":"observed_relationship","label":"The growth-suppressing response depended on a specific transcription factor.","description":"Foxo3 deletion, unlike Foxo1 deletion, made mouse stem/progenitor cells resistant to butyrate-mediated proliferation suppression.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e003cfb7-f795-582d-a3d1-6a0b8fd95151","slug":"mouse-foxo3","display_name":"Mouse forkhead transcription factor Foxo3","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3f0b9f24-c335-5642-91b8-13e4d47f904f","slug":"mouse-crypt-stem-proliferation","display_name":"Mouse colonic stem/progenitor-cell proliferation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f21a8b7c-4b28-532f-b401-0d3a29fcde76","slug":"mouse-foxo1","display_name":"Mouse forkhead transcription factor Foxo1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary full text, Figure 7","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse genetic stem-cell experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Loss of a response is not rescue of a nutrient deficiency. Correction record: A published erratum is confirmed by PubMed and publisher/Crossref metadata: Cell 167(4):1137, 2016. The notice body was not available through the accessed publisher endpoints. The main article's Acads/Foxo3 and crypt experiments were read, but the specific effect of the correction remains unassessed. https://pubmed.ncbi.nlm.nih.gov/27814510/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The growth-suppressing response depended on a specific transcription factor.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27264604/ · DOI 10.1016/j.cell.2016.05.018","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"195e2020-2c0a-5aba-ab55-aa94a08b1885","evidence_kind":"source_excerpt","locator":"Lines 326-332","start_line":326,"end_line":332,"excerpt":"## butyrate-foxo3-loss\nThe growth-suppressing response depended on a specific transcription factor.\nFoxo3 deletion, unlike Foxo1 deletion, made mouse stem/progenitor cells resistant to butyrate-mediated proliferation suppression.\nModel: Mouse genetic stem-cell experiments.\nLimitations: Loss of a response is not rescue of a nutrient deficiency. Correction record: A published erratum is confirmed by PubMed and publisher/Crossref metadata: Cell 167(4):1137, 2016. The notice body was not available through the accessed publisher endpoints. The main article's Acads/Foxo3 and crypt experiments were read, but the specific effect of the correction remains unassessed. https://pubmed.ncbi.nlm.nih.gov/27814510/\nEvidence access: Primary full text, Figure 7\nThe Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27264604/ · DOI 10.1016/j.cell.2016.05.018","model_system":"Mouse genetic stem-cell experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"33205bb8-dcbe-5d2c-afca-86075d7748d1","stable_key":"import-104835a3-b891-5dc4-a6bb-42ab7c6f96c4","title":"Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"a1253eb4426fc45d7b7c113028aa4ba2e9f89a9653272f3795437fc222bad558","revision_id":"c2320e65-a252-57a9-8838-7abf3d23400e","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}