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Mouse STIM1 stays distinct from the human selenium-linked STIM1 record.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"dim","display_name":"3,3'-Diindolylmethane / DIM","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Mouse muscle, mouse C2C12 myotubes and C. elegans","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"This is a candidate mechanism to test in humans, not an established treatment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[dim-p42308990] 3,3'-Diindolylmethane ameliorates muscle atrophy by modulating mitochondrial function and calcium homeostasis. (2026). https://pubmed.ncbi.nlm.nih.gov/42308990/ DOI: 10.1016/j.phymed.2026.158409","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Mitochondrial function and store-operated calcium entry","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"17c4b78c-9166-5904-9d3e-3eb66308d007","evidence_kind":"source_excerpt","locator":"Lines 1481-1492","start_line":1481,"end_line":1492,"excerpt":"### dim-muscle-atrophy\nDIM attenuated dexamethasone-induced myotube and mouse muscle atrophy and improved mouse grip-strength measures.\nCondition category: normal\nnutrient_topic: Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: This is a candidate mechanism to test in humans, not an established treatment.\norganism: Mouse muscle, mouse C2C12 myotubes and C. elegans\ntissue_or_cell_type: Mitochondrial function and store-operated calcium entry\nexperimental_model: Dexamethasone atrophy and aging-model experiments\nlimitations: 2026 preclinical study, not a human sarcopenia trial. Mouse STIM1 stays distinct from the human selenium-linked STIM1 record.\nexposure: DIM in experimental atrophy/aging models\nevidence_span: {\"source_cache\": \"artifacts/dim-research/42308990.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4bd26fd33c370df293346c5680820459a885a7545286d92c9e1c27220d41f2cb\", \"start_char\": 0, \"end_char\": 2803, \"text_sha256\": \"4bd26fd33c370df293346c5680820459a885a7545286d92c9e1c27220d41f2cb\"}\n[dim-p42308990] 3,3'-Diindolylmethane ameliorates muscle atrophy by modulating mitochondrial function and calcium homeostasis. (2026). https://pubmed.ncbi.nlm.nih.gov/42308990/ DOI: 10.1016/j.phymed.2026.158409","model_system":"Dexamethasone atrophy and aging-model experiments","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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