{"id":"9c6d618a-1219-50d2-9713-dc20c2740457","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-rat-oat","predicate":"reduces_activity","statement":"Rat liver ornithine aminotransferase activity decreased with silicon deprivation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"280664f7-ef15-52aa-b1a5-52d515fdfafc","mechanism_event_label":"A proline-related metabolic enzyme changed alongside collagen endpoints.","subject":{"id":"9531a6b4-f784-5368-a151-97ed206a8f0b","slug":"rat-low-silicon-diet","display_name":"Low-silicon experimental rat diet","entity_type_key":"cellular_process"},"object":{"id":"0394ad45-eda3-5681-9b75-8333860053f5","slug":"rat-oat","display_name":"Rat ornithine aminotransferase / OAT","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"280664f7-ef15-52aa-b1a5-52d515fdfafc","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-rat-oat-event","event_type":"observed_relationship","label":"A proline-related metabolic enzyme changed alongside collagen endpoints.","description":"Rat liver ornithine aminotransferase activity decreased with silicon deprivation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9531a6b4-f784-5368-a151-97ed206a8f0b","slug":"rat-low-silicon-diet","display_name":"Low-silicon experimental rat diet","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0394ad45-eda3-5681-9b75-8333860053f5","slug":"rat-oat","display_name":"Rat ornithine aminotransferase / OAT","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"11b1cdb5-1b10-586b-9917-b4da18ac072f","slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"2f57cb45-1fbb-5993-a28b-11e3b71040cc","slug":"sodium-metasilicate","display_name":"Sodium metasilicate","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"70ccd53c-83ad-5251-a4f5-6370973bc40a","slug":"l-proline","display_name":"L-Proline","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat dietary comparison; liver enzyme assay.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Activity change does not prove silicon is an OAT cofactor or a direct link to vitamin B6 depletion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"A proline-related metabolic enzyme changed alongside collagen endpoints.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Silicon deprivation decreases collagen formation in wounds and bone, and ornithine transaminase enzyme activity in liver. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12462748/ · DOI 10.1385/bter:89:3:251","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"251c095c-1a16-593d-8c80-533511ab590b","evidence_kind":"source_excerpt","locator":"Lines 360-366","start_line":360,"end_line":366,"excerpt":"## silica-rat-oat\nA proline-related metabolic enzyme changed alongside collagen endpoints.\nRat liver ornithine aminotransferase activity decreased with silicon deprivation.\nModel: Rat dietary comparison; liver enzyme assay.\nLimitations: Activity change does not prove silicon is an OAT cofactor or a direct link to vitamin B6 depletion.\nEvidence access: Primary abstract\nSilicon deprivation decreases collagen formation in wounds and bone, and ornithine transaminase enzyme activity in liver. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12462748/ · DOI 10.1385/bter:89:3:251","model_system":"Rat dietary comparison; liver enzyme assay.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc4b461e-dd46-57ab-8213-8aeb7ff9e8d0","stable_key":"import-3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd","title":"Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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