{"id":"9c6c19f5-75c5-5311-a226-f6aedd250f19","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-caret-combination-lung-cancer","predicate":"combined_with_carotene_increases","statement":"CARET found increased lung-cancer incidence with beta-carotene plus retinyl palmitate versus placebo (relative risk 1.28).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6d6381f4-7b4b-57a7-8244-064f815c6f3f","mechanism_event_label":"Combining the two forms did not produce the hoped-for protection.","subject":{"id":"62e3f5bd-503b-5ea8-b102-966aa3b7319c","slug":"retinyl-palmitate","display_name":"All-trans-retinyl palmitate","entity_type_key":"small_molecule"},"object":{"id":"3bb44f1d-7e92-50e1-be0a-39fad28bfff7","slug":"lung-cancer-incidence","display_name":"Lung cancer incidence","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6d6381f4-7b4b-57a7-8244-064f815c6f3f","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-caret-combination-lung-cancer-event","event_type":"observed_intervention","label":"Combining the two forms did not produce the hoped-for protection.","description":"CARET found increased lung-cancer incidence with beta-carotene plus retinyl palmitate versus placebo (relative risk 1.28).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"73c24cd4-9ae8-5897-8359-fa4d9e8edecb","slug":"beta-carotene","display_name":"All-trans-beta-carotene","entity_type_key":"small_molecule"},"role":"coadministered_agent","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"62e3f5bd-503b-5ea8-b102-966aa3b7319c","slug":"retinyl-palmitate","display_name":"All-trans-retinyl palmitate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"3bb44f1d-7e92-50e1-be0a-39fad28bfff7","slug":"lung-cancer-incidence","display_name":"Lung cancer incidence","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"18,314 high-risk participants; 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topical membership is not evidence of a direct dietary effect.\nplain_language: Combining the two forms did not produce the hoped-for protection.\norganism: Homo sapiens\ntissue_or_cell_type: Clinical lung-cancer incidence\nexperimental_model: 18,314 high-risk participants; mean four years.\nlimitations: Combined intervention cannot separate the contribution of each ingredient or establish their biochemical interaction.\nexposure: 30 mg/day beta-carotene plus 25,000 IU/day preformed vitamin A; trial stopped early.\n[va-omenn1996] Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease (1996). https://pubmed.ncbi.nlm.nih.gov/8602180/ DOI: 10.1056/nejm199605023341802","model_system":"18,314 high-risk participants; mean four years.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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