{"id":"9c3ce00d-aeff-55a6-9f2f-c5331fd3b77c","stable_key":"7484635e-cc8f-5cd6-a978-6dc5775a7db5:berberine-diabetes-hba1c","predicate":"changes","statement":"Berberine lowered HbA1c from 7.5% to 6.6% in its treatment arm, with a significant difference from placebo.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"751bc77e-d8e3-5203-bf33-688e9995c4fc","mechanism_event_label":"This trial measured improved glycemic control in people with diabetes.","subject":{"id":"7bbe0633-b2f1-510f-adc0-3c4d0ddad05d","slug":"berberine","display_name":"Berberine","entity_type_key":"small_molecule"},"object":{"id":"5deaa98d-e81e-521d-b810-a9228333e4ca","slug":"glycated-hemoglobin-concentration","display_name":"Glycated hemoglobin / HbA1c concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"751bc77e-d8e3-5203-bf33-688e9995c4fc","stable_key":"7484635e-cc8f-5cd6-a978-6dc5775a7db5:berberine-diabetes-hba1c-event","event_type":"observed_intervention","label":"This trial measured improved glycemic control in people with diabetes.","description":"Berberine lowered HbA1c from 7.5% to 6.6% in its treatment arm, with a significant difference from placebo.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7bbe0633-b2f1-510f-adc0-3c4d0ddad05d","slug":"berberine","display_name":"Berberine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5deaa98d-e81e-521d-b810-a9228333e4ca","slug":"glycated-hemoglobin-concentration","display_name":"Glycated hemoglobin / HbA1c concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/berberine-research/18397984.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0711d6853427d4b78af4704fd7630e08ed0f83d599311156dbc8570efd88dce2\", \"start_char\": 0, \"end_char\": 1715, \"text_sha256\": \"0711d6853427d4b78af4704fd7630e08ed0f83d599311156dbc8570efd88dce2\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized placebo-controlled clinical trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Berberine 1 g/day for three months","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Short trial with surrogate endpoints. Within-arm clamp improvement was not statistically significant versus placebo; lower glucose does not identify one causal enzyme.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Berberine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"berberine","display_name":"Berberine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"116 people with type 2 diabetes and dyslipidemia","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"This trial measured improved glycemic control in people with diabetes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[berberine-p18397984] Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. (2008). https://pubmed.ncbi.nlm.nih.gov/18397984/ DOI: 10.1210/jc.2007-2404","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Glycemic markers, lipids and insulin sensitivity","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"cfb74ea6-9b4d-59e3-b3b8-4f7a55289884","evidence_kind":"source_excerpt","locator":"Lines 1182-1193","start_line":1182,"end_line":1193,"excerpt":"### berberine-diabetes-hba1c\nBerberine lowered HbA1c from 7.5% to 6.6% in its treatment arm, with a significant difference from placebo.\nCondition category: normal\nnutrient_topic: Berberine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: This trial measured improved glycemic control in people with diabetes.\norganism: 116 people with type 2 diabetes and dyslipidemia\ntissue_or_cell_type: Glycemic markers, lipids and insulin sensitivity\nexperimental_model: Randomized placebo-controlled clinical trial\nlimitations: Short trial with surrogate endpoints. Within-arm clamp improvement was not statistically significant versus placebo; lower glucose does not identify one causal enzyme.\nexposure: Berberine 1 g/day for three months\nevidence_span: {\"source_cache\": \"artifacts/berberine-research/18397984.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0711d6853427d4b78af4704fd7630e08ed0f83d599311156dbc8570efd88dce2\", \"start_char\": 0, \"end_char\": 1715, \"text_sha256\": \"0711d6853427d4b78af4704fd7630e08ed0f83d599311156dbc8570efd88dce2\"}\n[berberine-p18397984] Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. (2008). https://pubmed.ncbi.nlm.nih.gov/18397984/ DOI: 10.1210/jc.2007-2404","model_system":"Randomized placebo-controlled clinical trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [berberine-p18397984] Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. (2008). https://pubmed.ncbi.nlm.nih.gov/18397984/ DOI: 10.1210/jc.2007-2404","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"9bb61e1d-e5cf-5b05-a9ca-409291f7a313","stable_key":"import-7484635e-cc8f-5cd6-a978-6dc5775a7db5","title":"Berberine: metabolism, nutrient connections and drug interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"2f376a035ae79c93e62e2ea4a8d5385643bf16553f108d12b6a80c89e6d41f4c","revision_id":"2a099429-1c4a-55be-aa2c-0565d08bda80","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}