{"id":"9c1ed778-2b08-58e4-ac00-8515b9e0d1b9","stable_key":"649e861b-265a-5912-bc36-3a73e53ef892:l-serine-mouse-low-serine-retina","predicate":"when_lowered_increases","statement":"Experimentally lowering serine in mice increased retinal deoxysphingolipids and compromised visual function.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"008678ba-798f-5752-94ed-35d94414d7e1","mechanism_event_label":"Reduced availability can change the products of lipid synthesis.","subject":{"id":"c882cd0b-9d83-5b07-bd1c-fe4d45657dcb","slug":"l-serine","display_name":"L-Serine","entity_type_key":"small_molecule"},"object":{"id":"3b0d7829-06c8-5bc5-b5a5-aff0c6a257d0","slug":"mouse-low-serine-retinal-deoxysphingolipids","display_name":"Retinal deoxysphingolipid accumulation in low-serine mice","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"008678ba-798f-5752-94ed-35d94414d7e1","stable_key":"649e861b-265a-5912-bc36-3a73e53ef892:l-serine-mouse-low-serine-retina-event","event_type":"observed_relationship","label":"Reduced availability can change the products of lipid synthesis.","description":"Experimentally lowering serine in mice increased retinal deoxysphingolipids and compromised visual function.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c882cd0b-9d83-5b07-bd1c-fe4d45657dcb","slug":"l-serine","display_name":"L-Serine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3b0d7829-06c8-5bc5-b5a5-aff0c6a257d0","slug":"mouse-low-serine-retinal-deoxysphingolipids","display_name":"Retinal deoxysphingolipid accumulation in low-serine mice","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"4d9df16d-24fa-5dc5-ab2a-2369a6a0399d","slug":"1-deoxysphingolipids","display_name":"1-Deoxysphingolipids","entity_type_key":"lipid"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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unverified.","entity":null}],"evidence":[{"id":"9534846e-9a95-5343-91dc-e659732acb5f","evidence_kind":"source_excerpt","locator":"Lines 278-284","start_line":278,"end_line":284,"excerpt":"## l-serine-mouse-low-serine-retina\nReduced availability can change the products of lipid synthesis.\nExperimentally lowering serine in mice increased retinal deoxysphingolipids and compromised visual function.\nModel: Mouse low-serine model in the MacTel study.\nLimitations: Mouse manipulation is distinct from the observational human plasma comparison.\nEvidence access: Primary abstract\nSerine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31509666/ · DOI 10.1056/NEJMoa1815111","model_system":"Mouse low-serine model in the MacTel study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"70bcf57a-36bb-563f-9073-2d616e5f155a","stable_key":"import-649e861b-265a-5912-bc36-3a73e53ef892","title":"L-Serine: synthesis, one-carbon metabolism, lipids and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; 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