{"id":"9be35b27-ce12-55c1-afaf-ce2b43aa43bf","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-thiamine-2016-neurologic-response","predicate":"associated-with-resolution-of","statement":"In the 2016 case, neurological symptoms resolved after intravenous Mg was added to ongoing thiamine for documented hypomagnesemia.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"263b95f9-e2b8-59af-af11-dad0edc9703e","mechanism_event_label":"A patient improved with combined treatment after symptoms progressed during thiamine alone.","subject":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"object":{"id":"8f0c05f4-4c98-50cf-bb64-dec9f7467c34","slug":"wernicke-neurologic-symptoms","display_name":"Wernicke encephalopathy neurological symptoms","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"263b95f9-e2b8-59af-af11-dad0edc9703e","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-thiamine-2016-neurologic-response-event","event_type":"observed_intervention","label":"A patient improved with combined treatment after symptoms progressed during thiamine alone.","description":"In the 2016 case, neurological symptoms resolved after intravenous Mg was added to ongoing thiamine for documented hypomagnesemia.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"role":"continued treatment","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8f0c05f4-4c98-50cf-bb64-dec9f7467c34","slug":"wernicke-neurologic-symptoms","display_name":"Wernicke encephalopathy neurological symptoms","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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this does not establish a dietary threshold or universal treatment failure.\n[coughlan-2016-thiamine] Thiamine refractory Wernickes encephalopathy reversed with magnesium therapy (2016). https://pmc.ncbi.nlm.nih.gov/articles/PMC5093844/ DOI: 10.1136/bcr-2016-218046","model_system":"Single 34-year-old man with alcohol withdrawal and Wernicke encephalopathy during intravenous thiamine treatment.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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