{"id":"9bbb7e5d-9ea4-5a46-b6ad-9e2fcc04b4b0","stable_key":"97957230-601f-5dec-8524-0812be8fadbf:l-threonine-tumor-threonine-restriction","predicate":"when_restricted_reduces","statement":"Dietary threonine restriction reduced tumor t6A and slowed glioblastoma xenograft growth, augmenting tested chemotherapy and anti-mitotic therapy.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"992872fa-9590-54e3-bc32-469117c8e2ff","mechanism_event_label":"Tumor dependency led to an experimental dietary intervention in animals.","subject":{"id":"fcef4dc2-a7b6-5812-bc33-c8af3d83f4d0","slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"},"object":{"id":"06fe0899-77ae-5053-bd3b-1f12f3aba4aa","slug":"mouse-glioblastoma-xenograft-t6a-growth","display_name":"Glioblastoma xenograft t6A and growth in mice","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"992872fa-9590-54e3-bc32-469117c8e2ff","stable_key":"97957230-601f-5dec-8524-0812be8fadbf:l-threonine-tumor-threonine-restriction-event","event_type":"observed_relationship","label":"Tumor dependency led to an experimental dietary intervention in animals.","description":"Dietary threonine restriction reduced tumor t6A and slowed glioblastoma xenograft growth, augmenting tested chemotherapy and anti-mitotic therapy.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fcef4dc2-a7b6-5812-bc33-c8af3d83f4d0","slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"06fe0899-77ae-5053-bd3b-1f12f3aba4aa","slug":"mouse-glioblastoma-xenograft-t6a-growth","display_name":"Glioblastoma xenograft t6A and growth in mice","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5c27b149-da7e-5a90-8bd3-d4b2a42bb2ef","slug":"trna-threonylcarbamoyladenosine","display_name":"tRNA-bound N6-threonylcarbamoyladenosine / t6A37","entity_type_key":"rna"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"3114b5d2-04d2-59d6-88c3-c04eb28aeeff","slug":"yrdc","display_name":"Human threonylcarbamoyladenylate synthase / YRDC","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse xenografts linked to human glioblastoma stem-cell experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This study does not establish a safe or effective threonine-restricted diet for patients. Exact dietary protocol and drug schedules require full-text clinical translation review.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Threonine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Tumor dependency led to an experimental dietary intervention in animals.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Threonine fuels glioblastoma through YRDC-mediated codon-biased translational reprogramming. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38519786/ · DOI 10.1038/s43018-024-00748-7","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"2d649d07-c7d4-5fe4-b4c9-1262014398a3","evidence_kind":"source_excerpt","locator":"Lines 370-376","start_line":370,"end_line":376,"excerpt":"## l-threonine-tumor-threonine-restriction\nTumor dependency led to an experimental dietary intervention in animals.\nDietary threonine restriction reduced tumor t6A and slowed glioblastoma xenograft growth, augmenting tested chemotherapy and anti-mitotic therapy.\nModel: Mouse xenografts linked to human glioblastoma stem-cell experiments.\nLimitations: This study does not establish a safe or effective threonine-restricted diet for patients. Exact dietary protocol and drug schedules require full-text clinical translation review.\nEvidence access: Primary abstract\nThreonine fuels glioblastoma through YRDC-mediated codon-biased translational reprogramming. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38519786/ · DOI 10.1038/s43018-024-00748-7","model_system":"Mouse xenografts linked to human glioblastoma stem-cell experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"35396730-235a-537e-8a05-c6ef2960c509","stable_key":"import-97957230-601f-5dec-8524-0812be8fadbf","title":"L-Threonine: translation, intestinal barrier, metabolism and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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