{"id":"9b995f90-6ad2-5259-b702-bc0a53ac6d8e","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iodine-trans-a7-basolateral2026","predicate":"localizes_to","statement":"The 2026 Finnish SLC26A7 study reported basolateral SLC26A7 localization in human thyrocytes, with intense staining in hyperthyroid samples.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"8b039f18-a7d9-5296-9416-63f17f274c21","mechanism_event_label":"A later human thyroid study placed SLC26A7 on the blood-facing side.","subject":{"id":"6ae2ac42-e051-59b1-aabb-f8263f987ea4","slug":"slc26a7","display_name":"Human SLC26A7 anion transporter","entity_type_key":"protein"},"object":{"id":"01e13e9a-bc3c-5783-bf49-dabe84a1edc3","slug":"thyrocyte-basolateral-membrane","display_name":"Thyrocyte basolateral membrane","entity_type_key":"organelle"},"evidence_count":1,"mechanism_event":{"id":"8b039f18-a7d9-5296-9416-63f17f274c21","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iodine-trans-a7-basolateral2026-event","event_type":"observed_intervention","label":"A later human thyroid study placed SLC26A7 on the blood-facing side.","description":"The 2026 Finnish SLC26A7 study reported basolateral SLC26A7 localization in human thyrocytes, with intense staining in hyperthyroid samples.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"83b11ca6-52c7-5a1b-8c39-d9cdf89244e3","slug":"iodide","display_name":"Iodide ion","entity_type_key":"ion"},"role":"candidate_physiological_substrate","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6ae2ac42-e051-59b1-aabb-f8263f987ea4","slug":"slc26a7","display_name":"Human SLC26A7 anion transporter","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"01e13e9a-bc3c-5783-bf49-dabe84a1edc3","slug":"thyrocyte-basolateral-membrane","display_name":"Thyrocyte basolateral membrane","entity_type_key":"organelle"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Six human thyroid samples including two homozygous carriers, goitrous/hyperactive samples and controls; additional mouse models","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Six human tissue samples spanning carriers, goitrous/hyperactive tissues and controls; abstract-level tissue localization result.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small heterogeneous tissue set and abstract-only extraction; this differs from the 2019 apical result and does not prove all thyroid contexts share one location.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iodine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A later human thyroid study placed SLC26A7 on the blood-facing side.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iodine-trans-slc26a7-localization2026] Finnish-Enriched SLC26A7 Variant in Congenital Hypothyroidism: Clinical Spectrum, Thyroid Histopathology, and Expression Analysis. (2026). https://pubmed.ncbi.nlm.nih.gov/41791885/ DOI: 10.1177/10507256251411983","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human thyroid tissue","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"808f195f-3d18-590a-86e7-8ae853238719","evidence_kind":"source_excerpt","locator":"Lines 479-490","start_line":479,"end_line":490,"excerpt":"### iodine-trans-a7-basolateral2026\nThe 2026 Finnish SLC26A7 study reported basolateral SLC26A7 localization in human thyrocytes, with intense staining in hyperthyroid samples.\nCondition category: normal\nnutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A later human thyroid study placed SLC26A7 on the blood-facing side.\norganism: Homo sapiens\ntissue_or_cell_type: Human thyroid tissue\nexperimental_model: Six human thyroid samples including two homozygous carriers, goitrous/hyperactive samples and controls; additional mouse models\nlimitations: Small heterogeneous tissue set and abstract-only extraction; this differs from the 2019 apical result and does not prove all thyroid contexts share one location.\nexposure: Six human tissue samples spanning carriers, goitrous/hyperactive tissues and controls; abstract-level tissue localization result.\ncross_nutrient: false\n[iodine-trans-slc26a7-localization2026] Finnish-Enriched SLC26A7 Variant in Congenital Hypothyroidism: Clinical Spectrum, Thyroid Histopathology, and Expression Analysis. (2026). https://pubmed.ncbi.nlm.nih.gov/41791885/ DOI: 10.1177/10507256251411983","model_system":"Six human thyroid samples including two homozygous carriers, goitrous/hyperactive samples and controls; additional mouse models","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [iodine-trans-slc26a7-localization2026] Finnish-Enriched SLC26A7 Variant in Congenital Hypothyroidism: Clinical Spectrum, Thyroid Histopathology, and Expression Analysis. (2026). https://pubmed.ncbi.nlm.nih.gov/41791885/ DOI: 10.1177/10507256251411983","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"76da623d-a34a-5a5c-a942-d7571a85c486","stable_key":"import-aaa7baba-8689-56ab-ba1e-b71542bcb8e9","title":"Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a4885eb6f58bad4a4514c958b63834619e57b10aa7f694aa97d0f65c7d36548f","revision_id":"ea8001a1-b576-5eda-a193-883c7ad59b73","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[{"id":"a80ce16a-66c1-5181-a528-f84f4bde7dfc","title":"SLC26A7 thyroid membrane localization remains unsettled","kind":"contradiction","status":"open","why":"The 2019 human tissue study reports predominantly apical SLC26A7, whereas the 2026 human thyrocyte study reports basolateral localization. Both are published descriptions of the human thyroid protein, beyond simply different transport assay outcomes. The 2018 negative HEK293 efflux result and 2019 positive polarized-cell result are retained as experimental context, not independently counted as a contradiction.","resolution":"Unresolved physiological localization: retain tissue and assay context. The 2025 cryo-EM and patch-clamp study strengthens evidence for intrinsic iodide/chloride transport capacity but does not establish the net direction or membrane side in intact human thyroid. The 2026 source is abstract-only; do not claim its images resolve earlier tissue/antibody differences.","created_at":"2026-09-17 14:32:20","record_type":"conflict","display_label":"Recorded conflict","record_url":"/conflicts/a80ce16a-66c1-5181-a528-f84f4bde7dfc","sides":[{"conflict_id":"a80ce16a-66c1-5181-a528-f84f4bde7dfc","ordinal":0,"label":"2019: predominantly apical in human thyroid","revision_id":"ea8001a1-b576-5eda-a193-883c7ad59b73","start_line":323,"end_line":334,"quote":"### iodine-trans-a7-apical2019\nIshii et al. detected human thyroid SLC26A7 staining predominantly on the apical side facing the follicular lumen.\nCondition category: normal\nnutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: One human thyroid study placed SLC26A7 mainly toward the follicular space.\norganism: Homo sapiens\ntissue_or_cell_type: Thyroid follicular tissue\nexperimental_model: Human thyroid tissue; recombinant human SLC26A7 in Nthy, MDCK, COS-7 and HEK293T cells; two affected siblings\nlimitations: Other studies report basolateral localization; antibody, tissue and experimental context remain relevant.\nexposure: SLC26A7 immunofluorescence with NIS/pendrin localization comparisons; Fig. 1.\ncross_nutrient: false\n[iodine-trans-slc26a7-2019] Congenital goitrous hypothyroidism is caused by dysfunction of the iodide transporter SLC26A7. (2019). https://pubmed.ncbi.nlm.nih.gov/31372509/ DOI: 10.1038/s42003-019-0503-6","source_key":"import-aaa7baba-8689-56ab-ba1e-b71542bcb8e9","source_title":"Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17)","claim_ids":["e7eff50e-3b22-56d7-9e90-979ad4e89873"]},{"conflict_id":"a80ce16a-66c1-5181-a528-f84f4bde7dfc","ordinal":1,"label":"2026: basolateral in human thyrocytes","revision_id":"ea8001a1-b576-5eda-a193-883c7ad59b73","start_line":479,"end_line":490,"quote":"### iodine-trans-a7-basolateral2026\nThe 2026 Finnish SLC26A7 study reported basolateral SLC26A7 localization in human thyrocytes, with intense staining in hyperthyroid samples.\nCondition category: normal\nnutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A later human thyroid study placed SLC26A7 on the blood-facing side.\norganism: Homo sapiens\ntissue_or_cell_type: Human thyroid tissue\nexperimental_model: Six human thyroid samples including two homozygous carriers, goitrous/hyperactive samples and controls; additional mouse models\nlimitations: Small heterogeneous tissue set and abstract-only extraction; this differs from the 2019 apical result and does not prove all thyroid contexts share one location.\nexposure: Six human tissue samples spanning carriers, goitrous/hyperactive tissues and controls; abstract-level tissue localization result.\ncross_nutrient: false\n[iodine-trans-slc26a7-localization2026] Finnish-Enriched SLC26A7 Variant in Congenital Hypothyroidism: Clinical Spectrum, Thyroid Histopathology, and Expression Analysis. (2026). https://pubmed.ncbi.nlm.nih.gov/41791885/ DOI: 10.1177/10507256251411983","source_key":"import-aaa7baba-8689-56ab-ba1e-b71542bcb8e9","source_title":"Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17)","claim_ids":["9b995f90-6ad2-5259-b702-bc0a53ac6d8e"]}]}],"corrections":[],"research":null}