{"id":"9b8dc436-b538-50a4-9e06-439d23022898","stable_key":"d2e91bc7-8177-5ad3-ad9b-5d65813ce082:naringenin-xo-weak","predicate":"weakly_inhibits","statement":"Naringenin and its sulfate/glucuronide metabolites were weak inhibitors of xanthine oxidase in xanthine and 6-mercaptopurine oxidation assays.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"2c26faff-4d2a-50ea-b06c-6609c3b92780","mechanism_event_label":"Naringenin and its sulfate/glucuronide metabolites were weak inhibitors of xanthine oxidase in xanthine and 6-mercaptopurine oxidation assays.","subject":{"id":"2a9350f6-01cc-5bea-8213-cd3ebb1b05cf","slug":"naringenin","display_name":"Naringenin","entity_type_key":"small_molecule"},"object":{"id":"79bc8d50-6995-5f28-8bdc-87226e2373ef","slug":"xanthine-oxidase-xanthine-and-6mp-oxidation","display_name":"Xanthine oxidase-catalyzed xanthine and 6-mercaptopurine oxidation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2c26faff-4d2a-50ea-b06c-6609c3b92780","stable_key":"d2e91bc7-8177-5ad3-ad9b-5d65813ce082:naringenin-xo-weak-event","event_type":"observed_relationship","label":"Naringenin and its sulfate/glucuronide metabolites were weak inhibitors of xanthine oxidase in xanthine and 6-mercaptopurine oxidation assays.","description":"Naringenin and its sulfate/glucuronide metabolites were weak inhibitors of xanthine oxidase in xanthine and 6-mercaptopurine oxidation assays.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2a9350f6-01cc-5bea-8213-cd3ebb1b05cf","slug":"naringenin","display_name":"Naringenin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"79bc8d50-6995-5f28-8bdc-87226e2373ef","slug":"xanthine-oxidase-xanthine-and-6mp-oxidation","display_name":"Xanthine oxidase-catalyzed xanthine and 6-mercaptopurine oxidation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c63225c8-3bd0-5928-b5af-e5923a1405c3","slug":"xanthine-oxidase","display_name":"Xanthine oxidase / XOR","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"deeef9b0-5e9b-5570-b893-5c677fd5c52a","slug":"6-mercaptopurine","display_name":"6-Mercaptopurine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"0a8b817b-52c5-5b98-b1d8-d6677651744c","slug":"xanthine","display_name":"Xanthine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Naringenin, sulfate and glucuronide conjugates","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Acute enzyme incubation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. 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(2023). https://pubmed.ncbi.nlm.nih.gov/37734263/ DOI: 10.1016/j.biopha.2023.115548\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Cell-free xanthine oxidase assays","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2804932d-46eb-5c43-8a45-0505e6b1ee05","stable_key":"import-d2e91bc7-8177-5ad3-ad9b-5d65813ce082","title":"Naringenin: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. 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