{"id":"9b7f78d6-47a7-5c2c-96d1-f9b2fc629b6d","stable_key":"ca8e9e6a-6953-51ec-b712-2b06398a416d:ra-tea-metabolites","predicate":"reported_relationship","statement":"Human rosemary-tea study detected extensive conjugation and metabolite timing compatible with intestinal and colonic processing.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"95cee78d-5b62-5f71-8452-44fa3396b7ec","mechanism_event_label":"Human rosemary-tea study detected extensive conjugation and metabolite timing compatible with intestinal and colonic processing.","subject":{"id":"a691a906-9d68-5d1a-8121-7df9b1220234","slug":"rosemary-tea","display_name":"Rosemary tea preparation","entity_type_key":"botanical"},"object":{"id":"f7b3724f-f41c-58ed-8752-ce3cda2a04a2","slug":"human-rosemary-metabolite-kinetics","display_name":"Human rosemary-tea metabolite kinetics","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"95cee78d-5b62-5f71-8452-44fa3396b7ec","stable_key":"ca8e9e6a-6953-51ec-b712-2b06398a416d:ra-tea-metabolites-event","event_type":"experimental_observation","label":"Human rosemary-tea study detected extensive conjugation and metabolite timing compatible with intestinal and colonic processing.","description":"### ra-tea-metabolites\n\nHuman rosemary-tea study detected extensive conjugation and metabolite timing compatible with intestinal and colonic processing.\nForty-eight compounds were identified. Total phenol recovery of 22.3% is not intact RA bioavailability.\nModel and exposure: Healthy-human plasma and urine study; indexed primary abstract.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Bioavailability and nutrikinetics of rosemary tea phenolic compounds in humans. | 2021 | https://pubmed.ncbi.nlm.nih.gov/33509454/ | https://doi.org/10.1016/j.foodres.2020.109815 | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a691a906-9d68-5d1a-8121-7df9b1220234","slug":"rosemary-tea","display_name":"Rosemary tea preparation","entity_type_key":"botanical"},"role":"recorded factor","stoichiometry":null,"state_label":"as reported","sequence_order":0,"notes":""},{"entity":{"id":"f7b3724f-f41c-58ed-8752-ce3cda2a04a2","slug":"human-rosemary-metabolite-kinetics","display_name":"Human rosemary-tea metabolite kinetics","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"not_reported","sequence_order":1,"notes":""},{"entity":{"id":"6072a4ae-d563-5466-a1b2-6d280255d346","slug":"rosmarinic-acid","display_name":"Rosmarinic acid","entity_type_key":"small_molecule"},"role":"preparation constituent","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"049cdeae-4cd8-5eac-b3c5-5a24a235a945","slug":"caffeic-acid","display_name":"Caffeic acid","entity_type_key":"small_molecule"},"role":"hydrolysis-related metabolite","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"6f6f74e9-1946-5bb9-b9ec-10d144aca1ea","slug":"3-4-dihydroxyphenyllactic-acid","display_name":"3,4-Dihydroxyphenyllactic acid / danshensu","entity_type_key":"small_molecule"},"role":"hydrolysis-related metabolite","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Healthy-human plasma and urine study; indexed primary abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Recorded from source with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Rosmarinic acid collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"rosmarinic-acid","display_name":"Rosmarinic acid","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Human rosemary-tea study detected extensive conjugation and metabolite timing compatible with intestinal and colonic processing.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Bioavailability and nutrikinetics of rosemary tea phenolic compounds in humans. | https://pubmed.ncbi.nlm.nih.gov/33509454/ | https://doi.org/10.1016/j.foodres.2020.109815","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference ra-tea-metabolites; Forty-eight compounds were identified. Total phenol recovery of 22.3% is not intact RA bioavailability.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"45a06a42-b353-5fd0-8ed0-7a89a71f1494","evidence_kind":"source_excerpt","locator":"Lines 69-75","start_line":69,"end_line":75,"excerpt":"### ra-tea-metabolites\n\nHuman rosemary-tea study detected extensive conjugation and metabolite timing compatible with intestinal and colonic processing.\nForty-eight compounds were identified. Total phenol recovery of 22.3% is not intact RA bioavailability.\nModel and exposure: Healthy-human plasma and urine study; indexed primary abstract.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Bioavailability and nutrikinetics of rosemary tea phenolic compounds in humans. | 2021 | https://pubmed.ncbi.nlm.nih.gov/33509454/ | https://doi.org/10.1016/j.foodres.2020.109815 | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","model_system":"Healthy-human plasma and urine study; indexed primary abstract.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. Access level is explicit.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"606cff22-a6ed-59cd-a84d-87f44c59dc25","stable_key":"import-ca8e9e6a-6953-51ec-b712-2b06398a416d","title":"Rosmarinic acid: detailed mechanisms of action (reviewed 10 October 2026)","document_type":"imported_text","citation_label":"AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed.","file_path":"","sha256":"684b4eab1dc2c0057f679109770af0de9340af5cd933377b590298cf8a752956","revision_id":"4028d9c5-fb17-54c5-b72c-c6d21678a832","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}