{"id":"9b2c4e95-3a39-5024-9f6b-b43fb918bb99","stable_key":"35ec55a7-323c-5c28-979e-3bdafe9d5769:pca-macrophage-response","predicate":"context_dependent_observation","statement":"PCA reduced macrophage miR-10b and increased ABCA1/ABCG1-related cholesterol efflux in the reported experimental program.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"fb5e47ae-b81e-549a-aa08-df4a194a003e","mechanism_event_label":"PCA reduced macrophage miR-10b and increased ABCA1/ABCG1-related cholesterol efflux in the reported experimental program.","subject":{"id":"f7042803-09ec-53d9-9d4c-9a0ce4042c00","slug":"protocatechuic-acid","display_name":"Protocatechuic acid / 3,4-dihydroxybenzoic acid","entity_type_key":"small_molecule"},"object":{"id":"ec76bcae-90f8-5ec3-9ac5-102a3a8666ab","slug":"macrophage-mir10b-abca1-abcg1-response","display_name":"Macrophage miR-10b and ABCA1/ABCG1 response, species-specific PCA endpoints not fully extracted","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"fb5e47ae-b81e-549a-aa08-df4a194a003e","stable_key":"35ec55a7-323c-5c28-979e-3bdafe9d5769:pca-macrophage-response-event","event_type":"experimental_observation","label":"PCA reduced macrophage miR-10b and increased ABCA1/ABCG1-related cholesterol efflux in the reported experimental program.","description":"**PCA–miR-10b–cholesterol export is a specific experimental branch.** In ApoE-deficient mice, antibiotic depletion and microbiota reacquisition supported microbial involvement in C3G-to-PCA metabolism. 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Full paper required for species-separated PCA edges and exact concentrations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"PCA reduced macrophage miR-10b and increased ABCA1/ABCG1-related cholesterol efflux in the reported experimental program.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Gut microbiota metabolism of anthocyanin promotes reverse cholesterol transport in mice via repressing miRNA-10b. | 2012 | DOI 10.1161/circresaha.112.266502 | PMID 22821931 | https://pubmed.ncbi.nlm.nih.gov/22821931/ | https://doi.org/10.1161/circresaha.112.266502","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 66-66; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"88d6eeff-9f7a-5d34-b81a-ed46ec73f511","evidence_kind":"source_excerpt","locator":"Lines 66-66","start_line":66,"end_line":66,"excerpt":"**PCA–miR-10b–cholesterol export is a specific experimental branch.** In ApoE-deficient mice, antibiotic depletion and microbiota reacquisition supported microbial involvement in C3G-to-PCA metabolism. 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