{"id":"9af8c0c8-5288-578d-9335-954b5e30c8f5","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-tangerine-absorption","predicate":"increased","statement":"Tangerine tomato juice produced an 8.5-fold higher lycopene bioavailability response than red juice in this crossover trial.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6887251e-d8d6-5571-a07b-eb39b047b063","mechanism_event_label":"Both the shape of the molecule and its packaging in the tomato may matter.","subject":{"id":"07fa9571-8ade-504b-a129-b9ebd3df4bdd","slug":"tangerine-tomato-juice","display_name":"Study-specific tangerine tomato juice","entity_type_key":"chemical_species"},"object":{"id":"279fd193-6e16-5495-8e20-afc051d71985","slug":"lycopene-postprandial-trl-response","display_name":"Postprandial lycopene response in triglyceride-rich lipoproteins","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6887251e-d8d6-5571-a07b-eb39b047b063","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-tangerine-absorption-event","event_type":"biochemical_relationship","label":"Both the shape of the molecule and its packaging in the tomato may matter.","description":"Tangerine tomato juice produced an 8.5-fold higher lycopene bioavailability response than red juice in this crossover trial.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"756a3de2-d56f-534c-85a8-b45ad1302aa9","slug":"tetra-cis-lycopene","display_name":"Tetra-cis-lycopene / prolycopene","entity_type_key":"small_molecule"},"role":"predominant_isomer","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0b16e027-7a68-55ae-8e33-eae8b5cd1e9e","slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"},"role":"measured_carotenoid","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"07fa9571-8ade-504b-a129-b9ebd3df4bdd","slug":"tangerine-tomato-juice","display_name":"Study-specific tangerine tomato juice","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"279fd193-6e16-5495-8e20-afc051d71985","slug":"lycopene-postprandial-trl-response","display_name":"Postprandial lycopene response in triglyceride-rich lipoproteins","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/lycopene-research/25620547.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"bfcae4ee14a42c46972a911970a2cd85383c1f8ded5bf95b91dbae0e5c110d82\", \"start_char\": 0, \"end_char\": 1385, \"text_sha256\": \"bfcae4ee14a42c46972a911970a2cd85383c1f8ded5bf95b91dbae0e5c110d82\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized crossover meal trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"10 mg lycopene from tangerine juice, 94% cis, versus red juice, 10% cis; 12-hour sampling","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Isomer composition and crystalline versus globular food deposition changed together; cannot isolate isomer chemistry alone.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lycopene research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human, 11 adults","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Both the shape of the molecule and its packaging in the tomato may matter.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lycopene-p25620547] Enhanced bioavailability of lycopene when consumed as cis-isomers from tangerine compared to red tomato juice, a randomized, cross-over clinical trial. (2015). https://pubmed.ncbi.nlm.nih.gov/25620547/ DOI: 10.1002/mnfr.201400658","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma triglyceride-rich lipoproteins","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"58ce78fd-9994-595d-9b82-64b4807c447e","evidence_kind":"source_excerpt","locator":"Lines 182-193","start_line":182,"end_line":193,"excerpt":"### lycopene-tangerine-absorption\nTangerine tomato juice produced an 8.5-fold higher lycopene bioavailability response than red juice in this crossover trial.\nCondition category: normal\nnutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Both the shape of the molecule and its packaging in the tomato may matter.\norganism: Human, 11 adults\ntissue_or_cell_type: Plasma triglyceride-rich lipoproteins\nexperimental_model: Randomized crossover meal trial\nlimitations: Isomer composition and crystalline versus globular food deposition changed together; cannot isolate isomer chemistry alone.\nexposure: 10 mg lycopene from tangerine juice, 94% cis, versus red juice, 10% cis; 12-hour sampling\nevidence_span: {\"source_cache\": \"artifacts/lycopene-research/25620547.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"bfcae4ee14a42c46972a911970a2cd85383c1f8ded5bf95b91dbae0e5c110d82\", \"start_char\": 0, \"end_char\": 1385, \"text_sha256\": \"bfcae4ee14a42c46972a911970a2cd85383c1f8ded5bf95b91dbae0e5c110d82\"}\n[lycopene-p25620547] Enhanced bioavailability of lycopene when consumed as cis-isomers from tangerine compared to red tomato juice, a randomized, cross-over clinical trial. (2015). https://pubmed.ncbi.nlm.nih.gov/25620547/ DOI: 10.1002/mnfr.201400658","model_system":"Randomized crossover meal trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [lycopene-p25620547] Enhanced bioavailability of lycopene when consumed as cis-isomers from tangerine compared to red tomato juice, a randomized, cross-over clinical trial. (2015). https://pubmed.ncbi.nlm.nih.gov/25620547/ DOI: 10.1002/mnfr.201400658","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"d1e09874-8bde-548f-9664-26ad5eedb3c7","stable_key":"import-aad5a443-96e9-52eb-963a-812e90f9f896","title":"Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"9a53dd877de8b71d446f741026477c0fd70a38edac89f6f25339a371a627a59a","revision_id":"2e68d88d-a689-5959-9f9c-1552dd089c22","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}