{"id":"9af37ff0-faf6-5d8c-93d8-a547b04fadf0","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-iron-does-not-prevent-zinc-sod-fall","predicate":"does_not_prevent_zinc_associated_fall_in","statement":"Adding iron to the zinc intervention prevented adverse iron-status changes but did not prevent the fall in erythrocyte Cu/Zn-SOD activity.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6ea48c58-34af-592f-af2b-2b6ac253f6fe","mechanism_event_label":"Correcting the iron side of an interaction did not correct the copper-related enzyme endpoint.","subject":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"object":{"id":"09fadb77-b222-5d11-b365-077675f16d13","slug":"erythrocyte-cu-zn-sod-activity","display_name":"Erythrocyte copper/zinc superoxide dismutase activity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6ea48c58-34af-592f-af2b-2b6ac253f6fe","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-iron-does-not-prevent-zinc-sod-fall-event","event_type":"observed_intervention","label":"Correcting the iron side of an interaction did not correct the copper-related enzyme endpoint.","description":"Adding iron to the zinc intervention prevented adverse iron-status changes but did not prevent the fall in erythrocyte Cu/Zn-SOD activity.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"role":"shared intervention","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"09fadb77-b222-5d11-b365-077675f16d13","slug":"erythrocyte-cu-zn-sod-activity","display_name":"Erythrocyte copper/zinc superoxide dismutase activity","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/copper-research/2912000.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e2d70d43dded75edb026cac237f238d9e59399db6094098796e169f20e819443\", \"start_char\": 0, \"end_char\": 969, \"text_sha256\": \"e2d70d43dded75edb026cac237f238d9e59399db6094098796e169f20e819443\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Zinc versus zinc-plus-iron intervention","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"50 mg/day zinc with or without 50 mg/day iron for ten weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Study exposures, not dosing recommendations; erythrocyte enzyme activity and ceruloplasmin concentration are distinct endpoints.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Copper research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human adult females","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Correcting the iron side of an interaction did not correct the copper-related enzyme endpoint.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[copper-p2912000] Iron, copper, and zinc status: response to supplementation with zinc or zinc and iron in adult females. (1989). https://pubmed.ncbi.nlm.nih.gov/2912000/ DOI: 10.1093/ajcn/49.1.145","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Erythrocytes and serum","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"7ec0e443-6a11-5966-ad8a-dd2a31b5fee6","evidence_kind":"source_excerpt","locator":"Lines 1170-1181","start_line":1170,"end_line":1181,"excerpt":"### copper-iron-does-not-prevent-zinc-sod-fall\nAdding iron to the zinc intervention prevented adverse iron-status changes but did not prevent the fall in erythrocyte Cu/Zn-SOD activity.\nCondition category: normal\nnutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Correcting the iron side of an interaction did not correct the copper-related enzyme endpoint.\norganism: Human adult females\ntissue_or_cell_type: Erythrocytes and serum\nexperimental_model: Zinc versus zinc-plus-iron intervention\nlimitations: Study exposures, not dosing recommendations; erythrocyte enzyme activity and ceruloplasmin concentration are distinct endpoints.\nexposure: 50 mg/day zinc with or without 50 mg/day iron for ten weeks\nevidence_span: {\"source_cache\": \"artifacts/copper-research/2912000.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e2d70d43dded75edb026cac237f238d9e59399db6094098796e169f20e819443\", \"start_char\": 0, \"end_char\": 969, \"text_sha256\": \"e2d70d43dded75edb026cac237f238d9e59399db6094098796e169f20e819443\"}\n[copper-p2912000] Iron, copper, and zinc status: response to supplementation with zinc or zinc and iron in adult females. (1989). https://pubmed.ncbi.nlm.nih.gov/2912000/ DOI: 10.1093/ajcn/49.1.145","model_system":"Zinc versus zinc-plus-iron intervention","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [copper-p2912000] Iron, copper, and zinc status: response to supplementation with zinc or zinc and iron in adult females. (1989). https://pubmed.ncbi.nlm.nih.gov/2912000/ DOI: 10.1093/ajcn/49.1.145","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"9afba495-cbdc-51aa-998e-70a930dba3be","stable_key":"import-0ad8610d-d575-5870-b7cd-763a9f750783","title":"Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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