{"id":"9ab902c1-e1f6-5b92-aa58-6da37b737646","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-human-t10-fat","predicate":"no_significant_between_group_change","statement":"Fat mass and weight fell from baseline in the t10,c12 arm but not significantly more than placebo.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"557518b5-d5e7-57b1-b04f-e852cc8e8610","mechanism_event_label":"A before-and-after change was not a demonstrated treatment benefit.","subject":{"id":"4405f918-c17d-5365-b873-1678989f8ac1","slug":"cla-trans10-cis12","display_name":"trans-10,cis-12 conjugated linoleic acid","entity_type_key":"small_molecule"},"object":{"id":"40bb29d3-3656-556d-a376-12fb22e0c20a","slug":"human-cla-trial-fat-mass","display_name":"Human body fat mass in CLA trials","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"557518b5-d5e7-57b1-b04f-e852cc8e8610","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-human-t10-fat-event","event_type":"observed_relationship","label":"A before-and-after change was not a demonstrated treatment benefit.","description":"Fat mass and weight fell from baseline in the t10,c12 arm but not significantly more than placebo.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4405f918-c17d-5365-b873-1678989f8ac1","slug":"cla-trans10-cis12","display_name":"trans-10,cis-12 conjugated linoleic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"40bb29d3-3656-556d-a376-12fb22e0c20a","slug":"human-cla-trial-fat-mass","display_name":"Human body fat mass in CLA trials","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same 12-week trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Do not present within-group loss as superiority over placebo.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"CLA collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"conjugated-linoleic-acid","display_name":"Conjugated linoleic acid / CLA isomer family","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"A before-and-after change was not a demonstrated treatment benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12196420/ · DOI 10.2337/diacare.25.9.1516","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3a424766-785c-5e68-b2fd-c4945f61df28","evidence_kind":"source_excerpt","locator":"Lines 422-428","start_line":422,"end_line":428,"excerpt":"## cla-human-t10-fat\nA before-and-after change was not a demonstrated treatment benefit.\nFat mass and weight fell from baseline in the t10,c12 arm but not significantly more than placebo.\nModel: Same 12-week trial.\nLimitations: Do not present within-group loss as superiority over placebo.\nEvidence access: Primary abstract\nTreatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12196420/ · DOI 10.2337/diacare.25.9.1516","model_system":"Same 12-week trial.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"45cfa6e3-2e7d-57c1-8c35-65302b7b71db","stable_key":"import-ee4227e5-80d7-55e9-ada7-3c5a16f93ac9","title":"Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"f9fe73a8a4008d52061c65abe6de7a9806da75f1c478c5adace9387b8ffaad9e","revision_id":"21196d9c-aaab-5fe1-8f32-2987c94289c6","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}