{"id":"9a8ca4c0-967b-5291-aab3-bd3c910e41ca","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-histone-response","predicate":"controls_in_tested_cells","statement":"Methionine restriction changed SAM/SAH pools and rapidly reduced H3K4me3; restoring methionine restored the metabolic and methylation response.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"491216d0-266f-55a6-8543-a8d172c31967","mechanism_event_label":"Availability changed a specific chromatin mark, reversibly.","subject":{"id":"9d39f561-740b-5f67-bba7-8a72ef612a99","slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"},"object":{"id":"3244a358-3c2d-5ebf-bd5d-bf1cdad652fa","slug":"human-hct116-h3k4me3","display_name":"H3K4 trimethylation in human HCT116 cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"491216d0-266f-55a6-8543-a8d172c31967","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-histone-response-event","event_type":"observed_relationship","label":"Availability changed a specific chromatin mark, reversibly.","description":"Methionine restriction changed SAM/SAH pools and rapidly reduced H3K4me3; 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