{"id":"9a73a1dd-8583-5049-8773-9f49c35ac43e","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zinc-trans-zip5-influx","predicate":"increases","statement":"Mouse ZIP5 expression increased cellular Zn(II) uptake and showed selectivity for zinc among the potential substrates tested.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"4e49e8f1-a893-583e-98f7-410729bdda66","mechanism_event_label":"Mouse ZIP5 can move zinc into cells.","subject":{"id":"5d71153b-6474-5bc7-89ff-666b940683da","slug":"mouse-slc39a5","display_name":"Mouse ZIP5 (Slc39a5)","entity_type_key":"protein"},"object":{"id":"39158631-eef1-5e08-96a3-385ba1b5acf3","slug":"cellular-zinc-influx","display_name":"Cellular zinc influx","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4e49e8f1-a893-583e-98f7-410729bdda66","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zinc-trans-zip5-influx-event","event_type":"biochemical_relationship","label":"Mouse ZIP5 can move zinc into cells.","description":"Mouse ZIP5 expression increased cellular Zn(II) uptake and showed selectivity for zinc among the potential substrates tested.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"49c806c2-7041-5020-8b3b-fa04ffa122ac","slug":"zinc-ion","display_name":"Zinc(II) ion","entity_type_key":"ion"},"role":"transported_substrate","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5d71153b-6474-5bc7-89ff-666b940683da","slug":"mouse-slc39a5","display_name":"Mouse ZIP5 (Slc39a5)","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"39158631-eef1-5e08-96a3-385ba1b5acf3","slug":"cellular-zinc-influx","display_name":"Cellular zinc influx","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Heterologous mouse ZIP5 expression","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Expression and substrate tests; abstract does not specify concentrations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Selectivity is bounded by the tested panel and assay; this cannot exclude every other substrate in other systems.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zinc research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mouse protein in cultured cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Mouse ZIP5 can move zinc into cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zinc-trans-15322118] The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells. (2004). https://pubmed.ncbi.nlm.nih.gov/15322118/ DOI: 10.1074/jbc.m408361200","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Cultured-cell plasma membrane","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e4015880-ab6f-5387-b6cb-7b920f6c4dd0","evidence_kind":"source_excerpt","locator":"Lines 362-373","start_line":362,"end_line":373,"excerpt":"### zinc-trans-zip5-influx\nMouse ZIP5 expression increased cellular Zn(II) uptake and showed selectivity for zinc among the potential substrates tested.\nCondition category: normal\nnutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Mouse ZIP5 can move zinc into cells.\norganism: Mouse protein in cultured cells\ntissue_or_cell_type: Cultured-cell plasma membrane\nexperimental_model: Heterologous mouse ZIP5 expression\nlimitations: Selectivity is bounded by the tested panel and assay; this cannot exclude every other substrate in other systems.\nexposure: Expression and substrate tests; abstract does not specify concentrations.\ncross_nutrient: false\n[zinc-trans-15322118] The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells. (2004). https://pubmed.ncbi.nlm.nih.gov/15322118/ DOI: 10.1074/jbc.m408361200","model_system":"Heterologous mouse ZIP5 expression","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [zinc-trans-15322118] The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells. (2004). https://pubmed.ncbi.nlm.nih.gov/15322118/ DOI: 10.1074/jbc.m408361200","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c5ee0fee-ce5c-58de-905a-10fb0ea0723c","stable_key":"import-6d38d43e-01e4-5641-93be-65654271e242","title":"Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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