{"id":"9a4c5e12-9b6a-599c-be93-abaea2b5132a","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-bhb-asc","predicate":"reduces","statement":"BHB reduced ASC oligomerization and speck formation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"f7e7dc6f-8340-5da5-9bb7-177560ba84a5","mechanism_event_label":"The inflammatory complex assembled less effectively.","subject":{"id":"59496369-eea6-5302-a0a3-2dcfa8f2b71a","slug":"d-beta-hydroxybutyrate","display_name":"D-(R)-beta-hydroxybutyrate","entity_type_key":"small_molecule"},"object":{"id":"0fe949ab-d6f7-5c13-8b6c-96d16c89e7b4","slug":"asc-oligomerization","display_name":"ASC oligomerization and speck formation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f7e7dc6f-8340-5da5-9bb7-177560ba84a5","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-bhb-asc-event","event_type":"observed_relationship","label":"The inflammatory complex assembled less effectively.","description":"BHB reduced ASC oligomerization and speck formation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"59496369-eea6-5302-a0a3-2dcfa8f2b71a","slug":"d-beta-hydroxybutyrate","display_name":"D-(R)-beta-hydroxybutyrate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0fe949ab-d6f7-5c13-8b6c-96d16c89e7b4","slug":"asc-oligomerization","display_name":"ASC oligomerization and speck formation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"d4f83161-d4b0-5b91-b3ed-84d44d2b2bae","slug":"pycard","display_name":"ASC / PYCARD","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"a732d76c-af99-5440-b172-400274462345","slug":"nlrp3-inflammasome","display_name":"NLRP3 inflammasome","entity_type_key":"protein_complex"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"NLRP3 activation models.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Effect did not require HCAR2, AMPK, autophagy or ketone oxidation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"}},{"dimension":"plain_language","value_text":"The inflammatory complex assembled less effectively.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25686106/ · DOI 10.1038/nm.3804","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"879dce86-d893-5484-9b89-3ce53b430c02","evidence_kind":"source_excerpt","locator":"Lines 376-382","start_line":376,"end_line":382,"excerpt":"## fast-bhb-asc\nThe inflammatory complex assembled less effectively.\nBHB reduced ASC oligomerization and speck formation.\nModel: NLRP3 activation models.\nLimitations: Effect did not require HCAR2, AMPK, autophagy or ketone oxidation.\nEvidence access: Primary abstract\nThe ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25686106/ · DOI 10.1038/nm.3804","model_system":"NLRP3 activation models.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"921d1eb5-2c88-52b9-9898-60b2b5bf6029","stable_key":"import-c9aa15a1-8ba2-5913-b2dd-372af304bf87","title":"Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"991b7fd94be84c0f1e622e0672eda03d600b388dfd7825e219aa1678d1c7983a","revision_id":"ce85d3f4-4eaf-5aee-bddb-0f0ce7fe2211","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}