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The authors’ inference from it, that aspirin must act on the heme group rather than by acetylating the protein, is contradicted by the mutant and crystallographic records in this collection and is not adopted here.\nexposure: Ibuprofen ingestion followed by 650 milligrams of aspirin, with recovery followed to 26 hours\nevidence_span: {\"source_cache\": \"artifacts/aspirin-research/6411052.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a685344a88574182dbad6f8d70308dce88384a63ed0c561ccaec4d522000b132\", \"start_char\": 0, \"end_char\": 1551, \"text_sha256\": \"a685344a88574182dbad6f8d70308dce88384a63ed0c561ccaec4d522000b132\"}\n[asa-p6411052] Ibuprofen protects platelet cyclooxygenase from irreversible inhibition by aspirin. 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