{"id":"99ecf0e2-1ee2-5964-aa1a-8406476f1ad7","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:hcl-acidemia-raises-plasma-k","predicate":"infusion-increases","statement":"HCl infusion causing acute mineral acidemia raised plasma potassium in the conscious-dog experiment.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"4cbe63ba-b781-564d-a7a4-d7929fba7411","mechanism_event_label":"Acid type affected the potassium response; a rise in blood potassium did not imply excess potassium intake.","subject":{"id":"1b9f5f66-3956-5538-8185-6c1542f2b65d","slug":"hydrochloric-acid","display_name":"Hydrochloric acid","entity_type_key":"chemical_species"},"object":{"id":"91de6063-d0ae-5f4c-9935-75bcec18c7b5","slug":"serum-potassium-concentration","display_name":"Serum or plasma potassium concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4cbe63ba-b781-564d-a7a4-d7929fba7411","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:hcl-acidemia-raises-plasma-k-event","event_type":"biochemical_relationship","label":"Acid type affected the potassium response; 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not potassium deficiency or excessive potassium intake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Twelve conscious dogs with portal/hepatic/systemic sampling; beta-hydroxybutyric acid 7 mEq/kg or HCl 3 mEq/kg infused over 30 minutes; additional anesthetized and obstructed-urinary-tract studies.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Acute HCl infusion, not every acidosis; portal glucagon rose and direct H/K exchange was not isolated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Canis lupus familiaris","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Acid type affected the potassium response; a rise in blood potassium did not imply excess potassium intake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[adrogue-1985-acid-infusion] Role of the endocrine pancreas in the kalemic response to acute metabolic acidosis in conscious dogs (1985). https://www.jci.org/articles/view/111775 DOI: 10.1172/JCI111775","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"systemic and splanchnic circulation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"478e75b7-a64d-5cf9-8df3-f125802fb6c5","evidence_kind":"source_excerpt","locator":"Lines 1151-1162","start_line":1151,"end_line":1162,"excerpt":"### hcl-acidemia-raises-plasma-k\nHCl infusion causing acute mineral acidemia raised plasma potassium in the conscious-dog experiment.\nCondition category: normal\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Acid type affected the potassium response; a rise in blood potassium did not imply excess potassium intake.\norganism: Canis lupus familiaris\ntissue_or_cell_type: systemic and splanchnic circulation\nexperimental_model: Twelve conscious dogs with portal/hepatic/systemic sampling; beta-hydroxybutyric acid 7 mEq/kg or HCl 3 mEq/kg infused over 30 minutes; additional anesthetized and obstructed-urinary-tract studies.\nlimitations: Acute HCl infusion, not every acidosis; portal glucagon rose and direct H/K exchange was not isolated.\nexperimental-exposure: Experimental acute mineral acidemia with hyperkalemia; not potassium deficiency or excessive potassium intake.\nendpoint: HCl infusion causing acute mineral acidemia raised plasma potassium in the conscious-dog experiment.\n[adrogue-1985-acid-infusion] Role of the endocrine pancreas in the kalemic response to acute metabolic acidosis in conscious dogs (1985). https://www.jci.org/articles/view/111775 DOI: 10.1172/JCI111775","model_system":"Twelve conscious dogs with portal/hepatic/systemic sampling; 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Study references: [adrogue-1985-acid-infusion] Role of the endocrine pancreas in the kalemic response to acute metabolic acidosis in conscious dogs (1985). https://www.jci.org/articles/view/111775 DOI: 10.1172/JCI111775","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"241226ee-6b7d-5cc7-9781-e6beb8ee1982","stable_key":"import-5102beb6-9f61-500e-af10-9ac63649e0b7","title":"Potassium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a8f89f8d84b48c0f93048dfc45f7f57a67dd9a7249968a096a14aeb03d8b7a52","revision_id":"de4ec6f4-58a1-537b-8169-97b783898df1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}