{"id":"9994d457-4ea0-50c4-8dc4-92f3702896cd","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-extract-caco2-flux","predicate":"increases_tested","statement":"Lovastatin flux across Caco-2 monolayers was higher with the three product extracts than with pure lovastatin at a matched 25 micromolar concentration.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"67b9eec5-8c96-530b-aebe-f55c9575970e","mechanism_event_label":"A cell-layer transport result supported a mixture effect.","subject":{"id":"479f127b-18e1-54db-b4d0-720ceaa77e28","slug":"ryr-methanol-extract-panel-2012","display_name":"LipoCol Forte, Xuezhikang and Cholestin extract panel studied in 2012","entity_type_key":"chemical_species"},"object":{"id":"b3d5a13d-da2f-5aab-add4-e3a873b8df2a","slug":"human-caco2-lovastatin-flux","display_name":"Human Caco-2 apical-to-basolateral lovastatin flux","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"67b9eec5-8c96-530b-aebe-f55c9575970e","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-extract-caco2-flux-event","event_type":"observed_relationship","label":"A cell-layer transport result supported a mixture effect.","description":"Lovastatin flux across Caco-2 monolayers was higher with the three product extracts than with pure lovastatin at a matched 25 micromolar concentration.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"479f127b-18e1-54db-b4d0-720ceaa77e28","slug":"ryr-methanol-extract-panel-2012","display_name":"LipoCol Forte, Xuezhikang and Cholestin extract panel studied in 2012","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b3d5a13d-da2f-5aab-add4-e3a873b8df2a","slug":"human-caco2-lovastatin-flux","display_name":"Human Caco-2 apical-to-basolateral lovastatin flux","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5d0ea9bb-cce8-5e13-aa3d-37db2215386e","slug":"lovastatin","display_name":"Lovastatin / monacolin K lactone","entity_type_key":"drug"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"c6139b52-4140-5622-9e33-1f6c6385265d","slug":"abcb1","display_name":"Human P-glycoprotein / ABCB1 / MDR1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text PMC3513969","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human intestinal-cell-line model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not quantify intestinal absorption or oral bioavailability in humans.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"red-yeast-rice","display_name":"Red yeast rice","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"A cell-layer transport result supported a mixture effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[23227093] Interaction between Red Yeast Rice and CYP450 Enzymes/P-Glycoprotein and Its Implication for the Clinical Pharmacokinetics of Lovastatin. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23227093/ · DOI 10.1155/2012/127043","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"03876316-28cf-5221-877e-703ff6df00d0","evidence_kind":"source_excerpt","locator":"Lines 140-146","start_line":140,"end_line":146,"excerpt":"## red-yeast-rice-extract-caco2-flux\nA cell-layer transport result supported a mixture effect.\nLovastatin flux across Caco-2 monolayers was higher with the three product extracts than with pure lovastatin at a matched 25 micromolar concentration.\nModel: Human intestinal-cell-line model.\nLimitations: Does not quantify intestinal absorption or oral bioavailability in humans.\nEvidence access: Primary full text PMC3513969\n[23227093] Interaction between Red Yeast Rice and CYP450 Enzymes/P-Glycoprotein and Its Implication for the Clinical Pharmacokinetics of Lovastatin. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23227093/ · DOI 10.1155/2012/127043","model_system":"Human intestinal-cell-line model.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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Not publisher full text.","file_path":"","sha256":"271bbcecaaacc76ad4d06718ae592dc6a1b33e3e459adfdd36cbd0ac5f09c0f6","revision_id":"9c30956c-206c-5c49-ae42-81b070088e26","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}