{"id":"996f120e-2bfb-572b-896d-7bc8c5da3e78","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-ras-interaction","predicate":"increases","statement":"Renin–angiotensin-system antagonists can increase steady-state lithium concentrations.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"dd663bd8-86d0-5f94-b8a6-1c6eda25545a","mechanism_event_label":"Blood-pressure medicines can change exposure.","subject":{"id":"69a299b5-3f94-51dc-9109-703e84cfbc45","slug":"renin-angiotensin-system-antagonist-exposure","display_name":"Renin–angiotensin-system antagonist exposure","entity_type_key":"cellular_process"},"object":{"id":"57835bde-69fc-5cc2-b68e-1254c4db4da6","slug":"human-serum-lithium","display_name":"Human serum lithium concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"dd663bd8-86d0-5f94-b8a6-1c6eda25545a","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-ras-interaction-event","event_type":"observed_relationship","label":"Blood-pressure medicines can change exposure.","description":"Renin–angiotensin-system antagonists can increase steady-state lithium concentrations.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"69a299b5-3f94-51dc-9109-703e84cfbc45","slug":"renin-angiotensin-system-antagonist-exposure","display_name":"Renin–angiotensin-system antagonist exposure","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"57835bde-69fc-5cc2-b68e-1254c4db4da6","slug":"human-serum-lithium","display_name":"Human serum lithium concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Official prescribing information","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Official prescribing information, sections 5, 7 and 12; updated 2026-07-06, prescribing text revised 2023-06.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Regulatory clinical statement; not an experiment resolving a single molecular target. No dosing recommendation follows.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"Blood-pressure medicines can change exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Lithium and lithium carbonate prescribing information; DailyMed set c84cce95-cfcb-4426-aac6-d2f48f946ada, updated July 6 2026; prescribing text revised June 2023 · 2026 · https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c84cce95-cfcb-4426-aac6-d2f48f946ada","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d0c069d5-d9f8-56da-b6f4-960f6b9c666f","evidence_kind":"source_excerpt","locator":"Lines 584-590","start_line":584,"end_line":590,"excerpt":"## lithium-ras-interaction\nBlood-pressure medicines can change exposure.\nRenin–angiotensin-system antagonists can increase steady-state lithium concentrations.\nModel: Official prescribing information, sections 5, 7 and 12; updated 2026-07-06, prescribing text revised 2023-06.\nLimitations: Regulatory clinical statement; not an experiment resolving a single molecular target. No dosing recommendation follows.\nEvidence access: Official prescribing information\nLithium and lithium carbonate prescribing information; DailyMed set c84cce95-cfcb-4426-aac6-d2f48f946ada, updated July 6 2026; prescribing text revised June 2023 · 2026 · https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c84cce95-cfcb-4426-aac6-d2f48f946ada","model_system":"Official prescribing information, sections 5, 7 and 12; updated 2026-07-06, prescribing text revised 2023-06.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b2dd2f3c-5c4c-5a12-9a0d-91b521ffcf98","stable_key":"import-b7798a90-72a3-5454-a321-c4be88bf0cc4","title":"Lithium: metal-sensitive enzymes, transport and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"dc67e965ba78458cf2d88d000d687641d9104354115ab16529a3a64941bd777d","revision_id":"4af127bf-9ccc-516b-9481-fafd453c2c35","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}