{"id":"99214699-ad6f-5659-b7c3-f1a2a04c3b18","stable_key":"911fb3c7-8cc3-5667-b677-5682fab67648:histidine-diet-skin","predicate":"supports","statement":"Five participants developed scaling, dryness and mild erythema during histidine-deficient feeding; these lesions and general symptoms resolved after repletion.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"4f57208b-febb-5fe9-8f66-c2394fa490c7","mechanism_event_label":"The controlled shortage also affected skin.","subject":{"id":"44374451-3436-5136-a8ae-5dcc6d8c353b","slug":"histidine","display_name":"L-Histidine","entity_type_key":"small_molecule"},"object":{"id":"24bb4f3c-b309-5963-a0ab-cd284af5b5bc","slug":"human-histidine-depletion-skin","display_name":"Skin condition during controlled histidine depletion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4f57208b-febb-5fe9-8f66-c2394fa490c7","stable_key":"911fb3c7-8cc3-5667-b677-5682fab67648:histidine-diet-skin-event","event_type":"observed_relationship","label":"The controlled shortage also affected skin.","description":"Five participants developed scaling, dryness and mild erythema during histidine-deficient feeding; these lesions and general symptoms resolved after repletion.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"44374451-3436-5136-a8ae-5dcc6d8c353b","slug":"histidine","display_name":"L-Histidine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"24bb4f3c-b309-5963-a0ab-cd284af5b5bc","slug":"human-histidine-depletion-skin","display_name":"Skin condition during controlled histidine depletion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Controlled sequential metabolic-unit feeding in four healthy and three chronically uremic men; histidine-deficient amino-acid diet for 35 +/- 2 days, followed by histidine-containing diet for 31 +/- 5 days.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small historical nonrandomized sequential study; mixed renal status and artificial diet. Does not define a universal plasma cutoff, ordinary dietary prevalence or replacement dose.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Histidine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"histidine","display_name":"L-Histidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The controlled shortage also affected skin.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Evidence that histidine is an essential amino acid in normal and chronically uremic man. · 1975 · https://pubmed.ncbi.nlm.nih.gov/1123426/ · DOI 10.1172/JCI108016","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"8c9c0169-6717-5126-8669-75322071370a","evidence_kind":"source_excerpt","locator":"Lines 50-56","start_line":50,"end_line":56,"excerpt":"## histidine-diet-skin\nThe controlled shortage also affected skin.\nFive participants developed scaling, dryness and mild erythema during histidine-deficient feeding; these lesions and general symptoms resolved after repletion.\nModel: Controlled sequential metabolic-unit feeding in four healthy and three chronically uremic men; histidine-deficient amino-acid diet for 35 +/- 2 days, followed by histidine-containing diet for 31 +/- 5 days.\nLimitations: Small historical nonrandomized sequential study; mixed renal status and artificial diet. Does not define a universal plasma cutoff, ordinary dietary prevalence or replacement dose.\nEvidence access: Primary abstract\nEvidence that histidine is an essential amino acid in normal and chronically uremic man. · 1975 · https://pubmed.ncbi.nlm.nih.gov/1123426/ · DOI 10.1172/JCI108016","model_system":"Controlled sequential metabolic-unit feeding in four healthy and three chronically uremic men; histidine-deficient amino-acid diet for 35 +/- 2 days, followed by histidine-containing diet for 31 +/- 5 days.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"ce59e6c9-1213-523b-9d0b-400b7a81cd1c","stable_key":"import-911fb3c7-8cc3-5667-b677-5682fab67648","title":"L-Histidine: supply, catabolism, histamine, receptors and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"cb672530ec8b4a4542d0f3957e80ca76bb0449e9f988845b0f7681f623c4ec9b","revision_id":"19a7f26c-d9a1-5411-a81d-025f3d98a452","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}