{"id":"98dc974a-4edb-5f3b-be2b-8c447350cf13","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-mouse-fmt","predicate":"transfers_improvement","statement":"Transferring gut contents from myricetin-treated donors improved recipient cardiac/barrier measurements and reduced TLR4/MyD88-pathway protein readouts.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"08a278c0-77cd-5ed2-9656-ce23e2936078","mechanism_event_label":"A transferable gut-associated effect was tested.","subject":{"id":"b8693f45-e352-588b-9e23-e26b47fb0a8c","slug":"myricetin-conditioned-mouse-gut-contents","display_name":"Gut contents from myricetin-treated diabetic mice","entity_type_key":"cellular_process"},"object":{"id":"38f3c324-7ff6-5b8b-8d32-f63485fdd536","slug":"mouse-myricetin-fmt-cardiac-response","display_name":"Mouse cardiac and barrier response to conditioned gut-content transplantation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"08a278c0-77cd-5ed2-9656-ce23e2936078","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-mouse-fmt-event","event_type":"observed_relationship","label":"A transferable gut-associated effect was tested.","description":"Transferring gut contents from myricetin-treated donors improved recipient cardiac/barrier measurements and reduced TLR4/MyD88-pathway protein readouts.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b8693f45-e352-588b-9e23-e26b47fb0a8c","slug":"myricetin-conditioned-mouse-gut-contents","display_name":"Gut contents from myricetin-treated diabetic mice","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"38f3c324-7ff6-5b8b-8d32-f63485fdd536","slug":"mouse-myricetin-fmt-cardiac-response","display_name":"Mouse cardiac and barrier response to conditioned gut-content transplantation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Diabetic mouse donor/recipient transplantation; parent myricetin checked by HPLC in transplant material.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not isolate one bacterium or metabolite as sufficient; absence of detected parent does not exclude all carried metabolites.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A transferable gut-associated effect was tested.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Myricetin alleviates diabetic cardiomyopathy by regulating gut microbiota and their metabolites. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38472186/ · DOI 10.1038/s41387-024-00268-4","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"338b72e7-f182-508e-bdc6-434fd41f7b0b","evidence_kind":"source_excerpt","locator":"Lines 556-562","start_line":556,"end_line":562,"excerpt":"## myricetin-mouse-fmt\nA transferable gut-associated effect was tested.\nTransferring gut contents from myricetin-treated donors improved recipient cardiac/barrier measurements and reduced TLR4/MyD88-pathway protein readouts.\nModel: Diabetic mouse donor/recipient transplantation; parent myricetin checked by HPLC in transplant material.\nLimitations: Does not isolate one bacterium or metabolite as sufficient; absence of detected parent does not exclude all carried metabolites.\nEvidence access: Primary full text\nMyricetin alleviates diabetic cardiomyopathy by regulating gut microbiota and their metabolites. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38472186/ · DOI 10.1038/s41387-024-00268-4","model_system":"Diabetic mouse donor/recipient transplantation; parent myricetin checked by HPLC in transplant material.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"58045cd9-3b27-5469-bb4b-e1c6a9bdca34","stable_key":"import-8182578e-8d21-598e-a3cb-e62d480d2251","title":"Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; 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