{"id":"98cfa332-e322-5c95-9ad7-d9aeb52b5a09","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-aging-worm-lifespan","predicate":"increases","statement":"Taurine supplementation extended C. elegans lifespan across the reported worm experiments, with dose-dependent effects.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"f6b2da8e-3cfb-5d79-8327-60f341b1b685","mechanism_event_label":"A separate organism also showed a survival response.","subject":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"object":{"id":"f9efd6d0-921c-5b94-b5f1-b2e72c963ed3","slug":"worm-taurine-lifespan","display_name":"C. elegans lifespan in the 2023 taurine study","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f6b2da8e-3cfb-5d79-8327-60f341b1b685","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-aging-worm-lifespan-event","event_type":"observed_relationship","label":"A separate organism also showed a survival response.","description":"Taurine supplementation extended C. elegans lifespan across the reported worm experiments, with dose-dependent effects.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f9efd6d0-921c-5b94-b5f1-b2e72c963ed3","slug":"worm-taurine-lifespan","display_name":"C. elegans lifespan in the 2023 taurine study","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text, Figure 1 and supplementary-cohort description","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"C. elegans intervention cohorts in the 2023 study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Organism-specific exposure and metabolism; not an additional human trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A separate organism also showed a survival response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Taurine deficiency as a driver of aging. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37289866/ · DOI 10.1126/science.abn9257","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"34453e1d-2575-5923-bae9-d067be664451","evidence_kind":"source_excerpt","locator":"Lines 601-607","start_line":601,"end_line":607,"excerpt":"## taurine-aging-worm-lifespan\nA separate organism also showed a survival response.\nTaurine supplementation extended C. elegans lifespan across the reported worm experiments, with dose-dependent effects.\nModel: C. elegans intervention cohorts in the 2023 study.\nLimitations: Organism-specific exposure and metabolism; not an additional human trial.\nEvidence access: Primary full text, Figure 1 and supplementary-cohort description\nTaurine deficiency as a driver of aging. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37289866/ · DOI 10.1126/science.abn9257","model_system":"C. elegans intervention cohorts in the 2023 study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c6cb77619a374d9b1b04830032fdd3b33d269d160df5baba3778fad5adf57db5","revision_id":"cc45c491-cc6a-5426-ab72-d7c6d26c3614","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}